background and purpose: soil is the main habitat of saprophytic and pathogenic fungi. mucormycetes are one of the most parts of soil fungi and certain members are among opportunistic fungi and can cause systemic fungal infections in immunocompromised patients. the majority of human and animal infections are caused by members of the genera rhizopus, mucor, rhizomucor, lichtheimia (absidia), cunn...

Previous studies have suggested that the focal accumulation of phagocytic leukocytes is an important feature of the host response in mucormycosis. To ascertain the basis for this influx of inflammatory cells, we evaluated the effect of members of the order Mucorales, including species from the genera Rhizopus, Absidia, and Mucor, on the chemotactic activity of normal human serum for neutrophils...

The fungus Rhizopus oryzae which belong to the order Mucorales is a unique test agent to study the effects of metabolic alterations on infection since it behaves differently in the metabolically normal and abnormal host. This fungus was originally isolated at autopsy from a diabetic patient who died with cerebral mucormycosis.' We have shown in previously reported experiments that inoculation o...

mucormycosis is a clinical entity attributed to opportunistic fungal infection of order mucorales. this includes several pathogenic subtypes. it commonly affects the rhinocerebral sites and the immunocompromized patients with devastating results. visceral mucormycosis is a relatively rare complication. we report the first free sigmoid colon perforation secondary to invasive mucormycosis and dis...

Bags of Pinus strobus wood chips with moisture contents of 38, 92, 164, and 217% (oven dry weight) were inoculated with Bursaphelenchus xylophilus and incubated at 30 C in order to determine the effect of wood moisture on nematode population development. Nematodes were extracted after 2, 4, 8, and 12 weeks. Population levels were greatest in wood chips with a moisture content of 38% and decreas...

BACKGROUND Aspergillus and Mucorales species cause severe infections in patients after hematopoietic stem cell transplantation (HSCT). Induction of antifungal CD4(+) T-helper type 1 (Th1) immunity is an appealing strategy to combat these infections. Immunotherapeutic approaches are so far limited because of a lack of antigens inducing protective T cells, their elaborate production, and the need...

BACKGROUND Invasive fungal tracheobronchitis (IFT) is a severe form of pulmonary fungal infection that is not limited to immunocompromised patients. Although respiratory failure is a crucial predictor of death, information regarding IFT in critically ill patients is limited. METHODS In this retrospective, multicenter, observational study, we enrolled adults diagnosed as having IFT who had bee...

Mucormycosis is a fungal infection of the sinuses, brain, or lungs that causes a mortality rate of at least 50% despite first-line therapy. Because angioinvasion is a hallmark of mucormycosis infections, we sought to define the endothelial cell receptor(s) for fungi of the order Mucorales (the fungi that cause mucormycosis). Furthermore, since patients with elevated available serum iron, includ...

BACKGROUND Invasive fungal infections by Mucorales or Aspergillus spp. are lethal infections in immune compromised patients. For these infections a multimodal approach is required. One potential tool for treating these infections is hyperbaric oxygen. OBJECTIVES To evaluate the clinical course and utility of hyperbaric oxygen in patients with invasive fungal infections by Mucorales or Aspergi...