Introduction & Objectives More and more evidence is emerging that microbiota are involved in the development and severity of oral mucositis, an inflammation and ulceration of the mucosa after chemotherapy. It is known that the microbiome is changed during mucositis and that chemotherapy is often complicated with local and even systemic infections. But still little is known about the role of ora...

PURPOSE This study was done to examine the incidence of oral mucositis in hematopoietic stem cell transplantation patients and to identify factors influencing oral mucositis and patient outcomes according to severity. METHODS In this retrospective study, data were collected from electronic medical records of 222 patients who had received hematopoietic stem cell transplantation. Oral mucositis...

BACKGROUND Objective was to determine whether prophylactic low level laser therapy (LLLT) reduces the risk of severe mucositis as compared to placebo or no therapy. METHODS MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials were searched until February 2014 for randomized controlled trials (RCTs) comparing prophylactic LLLT with placebo or no therapy in patients with cancer o...

Mucositis is a common and debilitating side effect of chemotherapy that manifests due to the inability of chemotherapy agents to discriminate between normal and neoplastic cells. This results in ulcerating lesions lining the gastrointestinal tract. Moreover, the development of efficacious treatments for small intestinal mucositis has been hindered as the pathobiology of mucositis is still not f...

BACKGROUND Oral mucositis is a common inflammatory complication in patients undergoing high-dose chemotherapy and radiation followed by haematopoietic stem cell transplantation (HSCT). Lactobacillus brevis CD2 has been proven efficacious in preventing chemoradiotherapy-induced oral mucositis in squamous cell carcinoma of head and neck. METHODS This phase II study aimed to evaluate the safety ...

Background: Treatment of cancer is increasingly effective, but associated with short and long term side effects, including oral mucositis or its associated pain in patients with cancer receiving chemotherapy or radiotherapy. Objective; To evaluate the clinical efficacy and safety of Methyl sulfonyl methane and N-acetyl cysteine in cancer chemotherapy and irradiation induced oral mucositis Mater...

BACKGROUND The purpose of this study was to assess predictors of mucositis in oropharyngeal and oral cavity cancer after definitive or adjuvant volumetric modulated arc radiotherapy (VMAT) +/- chemotherapy. METHODS Fifty patients were evaluated. Statistical analysis was performed for the following parameters as potential predictors of mucositis ≥ G2: total oral mucosa and oral mucosa minus ta...

BACKGROUND Oral mucositis is one of the most common side-effects of 5-fluorouracil (5-FU)-based chemotherapy. The objective of this study was to evaluate the effects of irsogladine maleate (IM) on fluorouracil-induced oral mucositis through a double-blind, placebo controlled trial. PATIENTS AND METHODS Patients (N = 66) were randomly assigned to receive either placebo or IM (4 mg/day for 14 c...

Considerable progress in research and clinical application has been made since the original guidelines for managing mucositis in cancer patients were published in 2004, and the first active drug for the prevention and treatment of this condition has been approved by the United States Food and Drug Administration and other regulatory agencies in Europe and Australia. These changes necessitate an...

INTRODUCTION Oral mucositis is an unavoidable complication occurring during the treatment of cancer by radiotherapy, concurrent chemoradiotherapy (CCRT), or chemotherapy. This is a painful sequelae, significantly affecting the nutritional intake and quality of life. MATERIALS AND METHODS A multicentric cross-sectional study was done at four cancer centers in Hyderabad. About 455 subjects of b...