Asthma with bronchial hypersecretion is a type of asthma that is poorly studied. Its pathogenesis is not well understood, but is probably related to innate impaired immunity, particularly with toll-like receptors (TLRs) and secretory mucins (MUC). OBJECTIVES 1) Define the clinical and inflammatory phenotype of asthma with bronchial hypersecretion of mucus. 2) Compare the type of mucin present...

Airway mucus hypersecretion is a frequent symptom associated with acute and chronic airway disease. Inhibition of mucus production or promotion of mucolysis not only relieved symptoms but also improved disease outcomes. There are numerous available mucoactive medicines for prescription, and how to select them properly for different diseases is important for clinical practice. So far, there is n...

Allergic bronchopulmonary aspergillosis (ABPA) is a most frequently recognised manifestation of pulmonary aspergillosis. Being an immunologically mediated disease, it usually occurs in atopic individuals and is caused by hypersensitivity reaction to aspergillus fumigatus. Patients with chronic obstructive pulmonary disease (COPD) have mucus hypersecretion and may favour occurrence of ABPA. Howe...

The pathogenesis of mucoinfective lung disease in cystic fibrosis (CF) patients likely involves poor mucus clearance. A recent model of mucus clearance predicts that mucus flow depends on the relative mucin concentration of the mucus layer compared with that of the periciliary layer; however, mucin concentrations have been difficult to measure in CF secretions. Here, we have shown that the conc...

The two most common diseases with airway obstruction from pre-school age are asthma and cystic fibrosis (CF). Airway diseases in infancy will not be discussed. For reasons of simplicity, asthma is defined as the complex coexistance of one or more of the symptoms wheeze, breathlessness, cough, mucus hypersecretion, which are either chronically or intermittently present and which are generally tr...

Impaired airway clearance is both an indication for and a consequence of an artificial airway. Frequently, translaryngeal intubation and/or tracheostomy are performed to clear secretions retained in the central airways. However, the presence of such an apparatus can also cause mucosal inflammation and significant mucus hypersecretion, predisposing to infection and encouraging atelectasis and hy...

We studied the effects of substances P administration on tracheal mucus viscoelasticity, water content, clearability and secretion rate. Six neutered adult male ferrets (weight 1.1-1.5 kg) were studied, on four occasions each. They were anaesthetized with ketamine and xylazine, and intubated shallowly. Control mucus (pre- and post-Ringer instillation) was compared with the mucus obtained follow...

BACKGROUND In asthma and chronic obstructive pulmonary disease (COPD), airway mucus hypersecretion contributes to impaired mucociliary clearance, mucostasis and, potentially, the development of mucus plugging of the airways. SUMMARY Excess mucus production can be targeted via therapies that focus on inhibition mucin synthesis, via reducing expression of mucin (MUC) genes, and/or inhibition of...