Anti-tuberculosis drug resistance is a major problem in tuberculosis (TB) control, particularly multi-drug resistance TB (MDR-TB). The objective of this study was to determine the prevalence of primary and acquired anti-TB drug resistance among newly diagnosed pulmonary TB (PTB) and relapse cases. Sputa were collected from newly diagnosed and relapse PTB patients. Drug susceptibility tests (DST...

BACKGROUND & OBJECTIVE Multi-drug resistant (MDR) Mycobacterium tuberculosis isolates may be transmitted within communities due to dense population and poor hygienic conditions. For proper management and control of MDR-TB, understanding drug susceptibility pattern of M. tuberculosis isolates and their transmission pattern in every health care setting are essential. In the present study, we atte...

Introduction. Mycobacterium tuberculosis is the causative agent of tuberculosis. Drug susceptibility testing performed by phenotypic and molecular tests. Commonly used for drug automated BACTEC system in a liquid culture medium. line probe tests was introduced almost 15 years ago. Recently whole genome sequencing (WGS) analysis M. strains demonstrated that genotyping drug-resistance could be ac...

conclusions the study revealed a high prevalence of multi-drug resistance (mdr), class 1 integron, sccmec type iii, and spa type t030 amongst mrsa associated with burn wounds in an iranian hospital. the existence of sccmec type iii in burn patients emphasizes the nosocomial origin of these strains. objectives the aim of this study was to determine the distribution and molecular types of mrsa in...

Three independent variants (G2, G4, G5), resistant to methylglyoxal bis(guanylhydrazone), an anticancer drug, have been isolated by single step selection from an adenovirus-transformed rat brain cell line (1). These variants display selective cross-resistance to several natural product drugs of dissimilar structure and action. Multidrug resistance has recently been shown to be caused by overexp...

Aim: We aimed this study to find the prevalence of depression among multi drug resistant (MDR) TB patients and its related determinants. Material methods: An observational cross-sectional was conducted at Jinnah Postgraduate Medical Center Karachi hospital, we enrolled 107 MDR-TB using non-probability consecutive sampling. Patients were evaluated for Patient Health Questionnaire-9 (PHQ-9). Prev...

Multi-antibiotic drug-resistant (MDR) gram-negative bacilli are becoming a major threat to the standard care of septic patients. Empiric antimicrobial drug regimens to cover likely bacterial pathogens have to be altered in keeping with the spread of MDR pathogens in the health care setting and in the community. Reliable antibiotics for broad spectrum coverage for sepsis such as extended spectru...

“Relentless and dizzying rise of antimicrobial resistance”has contributed in a large measure to the persistence of infections as a major cause of morbidity and mortality.The purpose of this study was to catalog the carrier prevalence of MDR bacteria at the community level. It was mainly focused on isolating carriers from anterior nares and the gut and to determine their antimicrobial susceptibi...

Little is known about the impact of drug resistance on recurrence in TB. We conducted a cohort study to measure the impact of multi-drug resistance (MDR) on TB recurrence over nine years in Henan Province China. We reviewed medical records and conducted field interviews of 100 MDR and 150 non-MDR TB patients who were treated between 2001 and 2002. We compared long-term recurrence rates, risk fa...