Bcr-Abl, a fusion protein generated by t(9;22)(q34;q11) translocation, plays a critical role in the pathogenesis of chronic myelogenous leukemia (CML). It has been shown that Bcr-Abl contains multiple functional domains and motifs and can disrupt regulation of many signaling pathways and cellular functions. However, the role of specific domains and motifs of Bcr-Abl or of specific signaling pat...

A 64-year-old man underwent MRCP for further examination of gallbladder stones and IPMN of branch-type (IPMN-Br) was pointed out. Yearly MRCP had revealed the gradual increase of the cystic components, marked dilation of the main pancreatic duct (MPD), and filling defects in the MPD. After follow-up for three years, he underwent pancreatoduodenectomy. Histologically, the dilated MPD and connect...

The lattice Boltzmann method for multi-component immiscible fluids is applied to simulations of the behaviour of a drop in a square pipe flow for various Reynolds numbers of 10<Re<500, Weber numbers of 0<We<250 and viscosity ratios of η=1/5, 1, 2 and 5. It is found that, for low Weber numbers, the drop moves straight along a stable position on the diagonal line of the pipe section, and it moves...

A 53-year-old male visited his primary physician for epigastric and back pain. Abdominal-enhanced computed tomography (CT) revealed a simple cyst of the pancreatic tail attached to the stomach. A distal main pancreatic duct (MPD) was clearly dilated, but no pancreatic tumor was identified around the stenosis of MPD by CT scan and magnetic resonance cholangiopancreatography (MRCP). Endoscopic re...

This study investigated collision avoidance between two walkers by focusing on the conditions that lead to avoidance manoeuvres in locomotor trajectories. Following the hypothesis of a reciprocal interaction, we suggested a mutual variable as a continuous function of the two walkers' states, denoted minimum predicted distance (MPD). This function predicts the risk of collision, and its evolutio...

Dry friction dampers are widely used to reduce vibration. The forced vibration response of a simplified turbine blade with a new kind of under-platform dry friction dampers is studied in this paper. The model consists of a clamped blade as two rigidly connected beams and two dampers in the form of masses which are allowed to slide along the blade platform in the horizontal direction and vibrate...

The connection of two building structures with dampers is one of the effective vibration control systems. In this vibration control system, both buildings have to possess different vibration properties in order to provide a higher vibration reduction performance. In addition to such condition of different vibration properties of both buildings, the connecting dampers also play an important role...

BACKGROUND/AIMS Diffuse or segmental irregular narrowing of the main pancreatic duct (MPD), as observed by endoscopic retrograde cholangiopancreatography (ERCP), is a characteristic feature of autoimmune pancreatitis (AIP). METHODS ERCP findings were retrospectively examined in 40 patients with AIP in whom irregular narrowing of the MPD was detected near the orifice. The MPD opening sign was ...

This Doctor's MPD Brochure provides basic information for MPD patients and their doctors to better find their way in order to improve proper diagnosis and manage

The paper presents a plastic analysis procedure based on the energy balance concept for performance based seismic retrofit of multi-story multi-bay masonry infilled reinforced concrete (R/C) frames with a ‘soft’ ground story using passive energy dissipation (PED) devices with the objective of achieving a target performance level of the retrofitted R/C frame for a given seismic hazard level at t...