multiple myeloma is a malignant plasma cell disorder that accounts for approximately 10% of all hematologic cancers. it is characterized by accumulation of clonal plasma cells, predominantly in the bone marrow. the prevalence of type 2 diabetes is increasing; therefore, it is expected that there will be an increase in the diagnosis of multiple myeloma with concomitant diabetes mellitus. the tre...

BACKGROUND Natalizumab (Tysabri, Biogen Idec and Elan Pharmaceuticals) significantly reduces the relapse rate and disability progression, and improves health-related quality of life (HRQoL), in patients with relapsing-remitting multiple sclerosis. We investigated the impact of natalizumab on patient-reported outcomes (PROs) in a real-world setting. METHODS PRO data were collected from patient...

The objective of this investigation was to determine whether heterogeneity of plasma renin substrate could be observed in states of steroid excess and various forms of hypertensive disease. In states of stimulated renin substrate production by estrogens or glucocorticoids, multiple forms of renin substrate were apparent when stimulation was excessive. Stimulation of substrate production caused ...

1. DNA polymerase from nuclear and supernatant fractions of cultured mouse L929 cells was fractionated on columns of Sephadex G-200, Sepharose 4B and of DEAEcellulose. Several peaks of activity are found on Sephadex chromatography and the distribution of activity between these depends on: (a) the source of the enzyme, i.e. nuclear or supernatant fraction; (b) the mode of extraction of the enzym...

Cladribine (2-chlorodeoxyadenosine) is an immunosuppressant drug previously evaluated in multiple sclerosis (MS) with variable results. We report six patients with aggressive relapsing MS who despite a poor response to other therapies had a favourable clinical evolution after cladribine. Four women and two men with a rapid increase in the number and severity of relapses leading to increasing di...

1. Treatment of a partly purified preparation of rat liver monoamine oxidase with the chaotropic agent sodium perchlorate caused the enzyme to migrate as a single band of activity on polyacrylamide-gel electrophoresis, whereas the untreated enzyme separated into a number of bands. 2. Treatment with the chaotropic agent caused no loss ofenzyme activity towards benzylamine, dopamine or tyramine. ...

This article gives an introduction to the multiple Dirichlet series arising from sums of twisted automorphic L-functions. We begin by explaining how such series arise from Rankin-Selberg constructions. Then more recent work, using Hartogs’ continuation principle as extended by Bochner in place of such constructions, is described. Applications to the nonvanishing of Lfunctions and to other probl...

This chapter discusses the phenomenon of polymorphism in organic and organometallic compounds. Polymorphism is first introduced and then, to give the work some context, background information is given concerning properties and techniques for characterizing the solid phases. In particular, desolvation and interconverstion are examined, and the gas–solid reactions are presented as a successful ro...

1. Acetylcholinesterase from human erythrocytes was solubilized with Triton X-100 in strong salt solution and partially purified by (NH(4))(2)SO(4) fractionation. This preparation showed three main bands of enzyme activity after electrophoresis on polyacrylamide gel and incubation with either alpha-naphthyl acetate or acetylthiocholine as enzyme substrate. Two of the multiple forms were complet...

The four isozymes of mushroom tyrosinase can be partially resolved by analytical electrophoresis on acrylamide gel. Three of the four have similar sedimentation coefficients around 7.2 S, while that of or-tyrosinase is 6.7 S. The molecular weight of /34yrosinase, calculated from sedhnentation velocity and diiIusion data, is 123,800, in good agreement with other published values for mushroom tyr...