The 17β-HSD3 enzyme plays a key role in treatment of prostate cancer and small inhibitorscan be used to efficiently target it. In the present study, the multiple linear regression (MLR),and support vector machine (SVM) methods were used to interpret the chemical structuralfunctionality against the inhibition activity of some 17β-HSD3inhibitors. Chemical structuralinformation were described thro...

In a multiple linear regression model, there are instances where one has to update the regression parameters. In such models as new data become available, by adding one row to the design matrix, the least-squares estimates for the parameters must be updated to reflect the impact of the new data. We will modify two existing methods of calculating regression coefficients in multiple linear regres...

Estimation of game addiction in children plays a major role the mental and physical development child. Therefore, Various scales are used to examine various input parameters (Age, Gender, Daily play time, etc.) employed scales. The purpose this study is project system that estimates whether child addicted when looking at parameters. Artificial Neural Networks (ANN) Multiple Linear Regression (M...

An adaptive neuro-fuzzy inference system (ANFIS) was developed using the subtractive clustering technique to study the air demand in low-level outlet works. The ANFIS model was employed to calculate vent air discharge in different gate openings for an embankment dam. A hybrid learning algorithm obtained from combining back-propagation and least square estimate was adopted to identify linear and...

The 17β-HSD3 enzyme plays a key role in treatment of prostate cancer and small inhibitorscan be used to efficiently target it. In the present study, the multiple linear regression (MLR),and support vector machine (SVM) methods were used to interpret the chemical structuralfunctionality against the inhibition activity of some 17β-HSD3inhibitors. Chemical structuralinformation were described thro...

In this work multiple linear regression (MLR) and artificial neural network (ANN) were used to predict the retention factors of 40 basic and neutral drugs in immobilized artificial membrane liquid chromatography. Two separate models were developed for prediction of solute retention in two mobile phase compositions which were used five identical descriptors. The standard errors in ANN calculatio...

INTRODUCTION Tacrolimus is an important immunosuppressive drug for organ transplantation patients. It has a narrow therapeutic range, toxic side effects, and a blood concentration with wide intra- and interindividual variability. Hence, it is of the utmost importance to monitor tacrolimus blood concentration, thereby ensuring clinical effect and avoiding toxic side effects. Prediction models fo...

COX-2 inhibitory activities of some 1,4-dihydropyridine and 5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives were modeled by quantitative structure–activity relationship (QSAR) using stepwise-multiple linear regression (SW-MLR) method. The built model was robust and predictive with correlation coefficient (R2) of 0.972 and 0.531 for training and test groups, respectively. The quality of the mod...

The measurement and prediction of dye concentration is important in the design, planning and management of wastewater treatment. Soft computing techniques can be used as a support tool for analyzing data and making prediction. In this study, Central Composite Design (CCD) and adaptive neuro-fuzzy inference system (ANFIS) are employed to identify and predict the output intensity ratio of light t...