multiple organ dysfunction syndromes

Journal: :Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2017

Joseph A Carcillo E Scott Halstead Mark W Hall Trung C Nguyen Ron Reeder Rajesh Aneja Bita Shakoory Dennis Simon

OBJECTIVES We hypothesize that three inflammation pathobiology phenotypes are associated with increased inflammation, proclivity to develop features of macrophage activation syndrome, and multiple organ failure-related death in pediatric severe sepsis. DESIGN Prospective cohort study comparing children with severe sepsis and any of three phenotypes: 1) immunoparalysis-associated multiple orga...

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