Introduction The purpose of this study was to determine the effect resistance exercise (RE)-induced hormonal changes on intramuscular cytokine gene expression after muscle damage in untrained men and women. Methods Men (n = 8, 22 ± 3 yr) women 19 1 completed two sessions 80 unilateral maximal eccentric knee extensions followed by either an upper body RE bout (EX) or a time-matched period (CON)....

To obtain insight into the etiology of deep pressure sores, understanding of the relationship between prolonged transverse loading and local muscle damage is required. To date, the amount and location of muscle damage have been determined by histological examination. In the present study, we determined whether T2-weighted high-resolution magnetic resonance imaging (MRI) can also be applied to e...

Objective(s): Pregabalin (PGB) is a new antiepileptic drug that has received FDA approval for patient who suffers from central neuropathic pain, partial seizures, generalized anxiety disorder, fibromyalgia and sleep disorders. This study was undertaken to evaluate the possible adverse effects of PGB on the muscular system of mice. Materials and Methods: To evaluate the effect of PGB on skeletal...

This study tested the relationship between the magnitude of muscle damage and both central and peripheral modulations during and after eccentric contractions of plantar flexors. Eleven participants performed 10 sets of 30 maximal eccentric contractions of the plantar flexors at 45°·s(-1). Maximal voluntary torque, evoked torque (peripheral component) and voluntary activation (central component)...

P OLYMYOSITIS (PM) and dermatomyositis (DM) are inflammatory muscle diseases of unknown etiology. There is strong evidence for cellular immune mechanisms of muscle damage in these disorders. In recent years, numerous autoantibodies have been identified in patients with myositis, but their role in producing this clinical syndrome is unknown. In this report, we summarize the current state of know...