Effects of activation of beta3-adrenoceptor (beta3-AR) have not been determined in the spontaneously tonic smooth muscle of the internal anal sphincter (IAS). The effects of disodium (R,R)-5-[2-[2-3-chlorophenyl)-2-hydroxyethyl]-amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316243), a selective beta3-AR agonist, on the basal smooth muscle tone and direct release of nitric oxide (NO) by c...

Banwait, Kuldip S. and Satish Rattan. Role of nitric oxide in 3-adrenoceptor activation on basal tone of internal anal sphincter. Am J Physiol Gastrointest Liver Physiol 285: G547–G555, 2003. First published May 7, 2003; 10.1152/ ajpgi.00545.2002.—Effects of activation of 3-adrenoceptor ( 3-AR) have not been determined in the spontaneously tonic smooth muscle of the internal anal sphincter (IAS...