Abstract Immune evasion of Mycobacterium tuberculosis (Mtb) facilitates intracellular bacterial growth. The mechanisms immune evasion, however, are still not fully understood. In this study, we reveal that tristetraprolin (TTP), one the best characterized RNA-binding proteins controlling stability target mRNAs, mediates innate mycobacteria. We found TTP knockout mice displayed reduced burden in...

From March 1979 to June 1980, we preliminary identified mycobacteria at the time of their initial isolation by colonial morphology, pigmentation, and growth rate. The definitive identifications were predicted accurately for 92% of the mycobacteria isolated from 108 patients. For laboratories that isolate relatively few different species of mycobacteria, the advantages of this approach are its s...

introduction: fish mycobacteriosis is caused by the non-tuberculous mycobacteria. infected fish are normally the primary source of infection, although non-tuberculous mycobacteria can be found in the environment. the present study was designed to  investigate the few recently found suspected cases of mycobacteriosis in iranian ornamental fish tanks.   materials and methods: pathological specime...

molecular isolation of biodegradable mycobacteria from water supplies of iranian hospitals background and objectives: some microorganisms, mainly members of two genera including pseudomonas and mycobacterium , were found to be capable of transforming and degrading of polluting agents. we herein report the isolation of a few mycobacteria with the ability to biodegrade organic and inorganic compo...

Mycobacterium tuberculosis is responsible for nearly 2 million deaths yearly. Upon inhalation, mycobacteria are engulfed by alveolar macrophages. These cells produce reactive oxygen and nitrogen intermediates (ROI’s and RNI’s), which normally kill pathogens, but are ineffective against invading mycobacteria. What ensues, is the formation of a tubercle to sequester the infected macrophages, and ...

Here, we report the complete genome sequence of Mycobacterium immunogenum type strain CCUG 47286, a nontuberculous mycobacterium. The whole genome has 5,573,781 bp and covers as many as 5,484 predicted genes. This genome contributes to the task of closing the still-existing gap of genomes of rapidly growing mycobacterial type strains.

exposure? After all, these are not called atypical mycobacteria for nothing.

In conclusion, it is important to realize that there is no "stand alone" assay for the identification of NTM. Many new species may not be recognized in all assays. Newer molecular tests are more accurate for identification than phenotypic tests and have significantly improved turnaround time. Clinical significance of an isolate should be determined, however, before committing resources for the ...

Abstract Nontuberculous mycobacteria can cause disseminated infections in immunocompromised patients and are challenging to treat because of antimicrobial resistance adverse effects prolonged multidrug treatment. We report successful treatment with bedaquiline, a novel antimycobacterial drug, as part combination therapy for 2 nontuberculous co-infected HIV.