OBJECTIVE To develop an epidemiological database of morbidity in the community as presented to general practitioners and to support epidemiological research in general practice. DESIGN The project is a sentinel network of 23 general practices in Northern Ireland that report the incidence of a list of selected diseases to a central unit for analysis. RESULTS Results are presented for depress...

BACKGROUND There is consistent evidence that depression symptoms predict long-term mortality following a myocardial infarction, and recent results show a dose-related gradient. The importance of other psychological variables remains unclear. METHODS This study examines the relative importance of depression, anxiety, anger, and social support in predicting 5-year cardiac-related mortality foll...

BACKGROUND Few studies have addressed the relationship between generalised anxiety disorder and cardiovascular prognosis using a diagnostic interview. AIMS To assess the association between generalised anxiety disorder and adverse outcomes in patients with myocardial infarction. METHOD Patients with acute myocardial infarction (n = 438) were recruited between 1997 and 2000 and were followed...

OBJECTIVE To see whether transient myocardial ischaemia on ambulatory monitoring after myocardial infarction is associated with ventricular arrhythmias. DESIGN A prospective study. SETTING The coronary care unit, general medical wards, and cardiorespiratory department of a major teaching hospital. PATIENTS 203 consecutive patients without specific exclusion criteria admitted with acute my...

BACKGROUND The Coronary Psychosocial Evaluation Studies trial demonstrated promising results for enhanced depression treatment to reduce cardiovascular risk of patients with acute coronary syndrome and comorbid depression, but the long-term effectiveness of this intervention is unclear. METHODS A total of 157 participants with persistent depression after hospitalization for acute coronary syn...

OBJECTIVES The aim of this study was to investigate plasma concentrations of four pro-inflammatory cytokines (IL17a, IL6, TNFα and IL12p70) in patients with myocardial infarction and to analyse them according to presence of depression observed during first 6 months after myocardial infarction. METHODS In 44 patients with the first acute STEMI (ST segment elevation myocardial infarction) plasm...

BACKGROUND Depression is prevalent among patients with myocardial infarction and is associated with a worse prognosis. However, little is known about its importance in patients with chronic stable angina. We conducted a retrospective population-based cohort study to determine the occurrence and predictors of developing depression in patients with a new diagnosis of chronic stable angina. In add...

AIMS To evaluate the prevalence and the independent prognosis of electrocardiographic left ventricular hypertrophy by voltage only, ST depression and negative T wave, isolated negative T wave and left ventricular hypertrophy plus ST depression and negative T wave for cardiac morbidity and mortality, without known ischaemic heart disease at baseline. METHODS AND RESULTS Follow-up data from the...

background: there is evidence that electrocardiographic (ecg) changes occur during elective cesarean section in parturients. these changes, mostly in the form of st-segment depression, have been noted in either regional anesthesia or general anesthesia. we performed this study to compare hemodynamic variables and electrocardiographic changes suggestive of myocardial ischemia following administr...

we discuss here an uncommon condition of neurogenic hypotension in the context of immunoglobulin light chain (amyloid light-chain) amyloidosis. th e most serious feature was autonomic nervous system impairment, mainly characterized by severe refractory orthostatic hypotension, which became progressively invalidating, forcing the patient to bed. moreover, since the systemic involvement of the di...