The clinical presentation and management of spontaneous rupture of the middle third of the oesophagus is described in two patients. Early presentation and treatment in one case led to uncomplicated recovery. In the other patient late presentation and diagnosis resulted in delayed surgical intervention with an unsuccessful outcome. The nature of this rare lesion is discussed and nine previously ...

Of all the mechanical complications after acute myocardial infarction (MI), cardiac rupture remains the most devastating, dramatic, and deadly. Continued improvements in the care of patients with acute MI have decreased the incidence of cardiac rupture over the past decade to under 3% in patients receiving reperfusion therapy,1 although autopsy evaluation of patients who died suddenly with acut...

Left ventricular wall rupture after acute myocardial infarction (MI) is a fatal complication with the risk of sudden cardiac death. Such contained rupture presents as aneurysmal dilatation of ventricular wall on echocardiography. Pseudoaneurysm with contained rupture sealed by pericardium needs early surgical intervention. Here, the authors present similar case mimicking as pseudoaneurysm on ec...

Senescence is a recognized mechanism of cardiovascular diseases; however, its contribution to myocardial fibrosis and rupture after infarction and the underlying mechanisms remain unclear. Here we showed that senescent cardiac fibroblasts markedly accumulated in heart after myocardial infarction. The expression of key senescence regulators, especially p53, was significantly up-regulated in the ...

Left ventricular (LV) remodeling after myocardial infarction (MI) results in LV dilation, a major cause of congestive heart failure and sudden cardiac death. Ischemic injury and the ensuing inflammatory response participate in LV remodeling, leading to myocardial rupture and LV dilation. Myeloperoxidase (MPO), which accumulates in the infarct zone, is released from neutrophils and monocytes lea...

and Infarction To the Editor: In the October 24, 2000, issue of Circulation, Ojio et al1 reported 20 cases of acute myocardial infarction in which the patients had had angiograms shortly before acute myocardial infarction. They found evidence of plaque rupture/thrombi in 60% of cases at least 3 days before infarction. Because one half of the patients developed stable angina within a month befor...

Myocardial bridging is a common coronary anomaly, which is generally described as a benign phenomenon. However, a growing number of studies consider this anomaly a relevant pathophysiological phenomenon with serious pathological consequences. Here we report on the case of an 88-year-old woman suffering from myocardial infarction and ventricular septal rupture, lacking any recognizable coronary ...

Rupture of the left ventricular free wall is a dramatic complication of acute myocardial infarction (MI) and occurs in about ten percent of patients with fatal acute MI. However, there are limited reports about right ventricular free wall rupture due to MI. In this case report, a patient with isolated right ventricular rupture following MI that was visualised with real-time transthoracic echoca...

Mitral regurgitation (MR) after myocardial infarction is a relatively common complication and its incidence is about 50%. One cause of MR after myocardial infarction is papillary muscle rupture, and this situation usually requires urgent surgical treatment. Since prognosis is favorable with early surgical intervention, early diagnosis of the underlying cause of mitral regurgitation is very impo...