UNLABELLED Bronchial mucoepidermoid tumors are uncommon neoplasms, morphologically similar to their salivary gland counterpart. The histogenesis is controversial. The aim of this study is to identify myoepithelial cells and speculate on their role in the origin of these tumors. METHODS AND RESULTS Sixteen bronchial mucoepidermoid tumor surgical specimens were formalin-fixed, paraffin-embedded...

BACKGROUND Matrix-producing carcinoma (MPC) of the breast is one variant type of metaplastic carcinoma. The cellular origin of MPC remains unclear. It has been suggested the tumor cells in MPC have the combined characteristics of both epithelial cells and mesenchymal cells. Several reports suggested that the tumor cells in MPC might originate from the myoepithelial cells, but others suggested t...

Pleomorphic adenoma is the most common salivary gland neoplasm, and it can be locally invasive, despite its slow growth. This study aimed to establish a novel cell line (AP-1) derived from a human pleomorphic adenoma sample to better understand local invasiveness of this tumor. AP-1 cell line was characterized by cell growth analysis, expression of epithelial and myoepithelial markers by immuno...

Pleomorphic adenoma (PA) is the most common benign tumor of major salivary glands and intra nasal PA unusual which may be misdiagnosed as malignancy. A 65-year-old female presented with unilateral bleeding obstruction in right cavity for 6 months. Local examination showed polypoid mass surgically excised. HPE classic triphasic component epithelial, myoepithelial cartilaginous stromal elements p...

Epithelial myoepthial carcinoma (EMEC) is rare, low grad tumor with epithelial and myoepithelial components frequent local recurrence, also called glycogen rich adenoma (clear cell pattern), myoepithelioma (spindle plamocytiod patterns), (if only differentiation marked cytologic atypia). Occurs most frequently in the major salivary glands accounts for approximately 1% of all gland neoplasms tha...

Breast cancer is a genetically and clinically heterogeneous disease, and the contributions of different target cells and different oncogenic mutations to this heterogeneity are not well understood. Here we report that mammary tumors induced by components of the Wnt signaling pathway contain heterogeneous cell types and express early developmental markers, in contrast to tumors induced by other ...

Benign and malignant tumours originating from myoepithelial cells are rarely seen in clinical practice. Myoepithelioma of the middle ear is a very rare condition. A 54-year-old woman was admitted to our department, complaining of ear fullness, otalgia, and tinnitus in the left ear beginning 4 years earlier. The tumor Diagnosed as the left ear benign myoepithelioma. The tumor was removed. The os...

Background: The breast cancer is the most prevalent cancer among women, on the other hand absence of myoepithelial cells play a pivotal role in pathogenesis of this cancer. Thus we aimed to investigate the possible abilities of the molecular assay technique to find a relationship between mammary serine protease inhibitor (Maspin) gene expression possibly secreted by my...

We have recently reported that salivary gland cells express the lymphatic endothelial cell marker podoplanin. The present study was aimed to immunohistochemically investigate the expression of the myoepithelial cell marker α-smooth muscle actin (SMA) on podoplanin-positive cells in mouse parotid and sublingual glands, and to elucidate podoplanin localization in salivary gland myoepithelial cell...