Low serum concentrations of micronutrients, intestinal abnormalities, and an inflammatory state have been associated with HIV progression. These may be ameliorated by micronutrients, N-acetyl cysteine, probiotics, and prebiotics. This review aims to integrate the evidence from clinical trials of these interventions on the progression of HIV. Vitamin B, C, E, and folic acid have been shown to de...

Acylases catalyze the hydrolysis of a range of S-substituted N-acetyl-L-cysteines. The hydrolysis of N-acetyl-L-cysteine is catalyzed by cytosolic acylase I, and activity is present in human endothelial cells and rat lung, intestinal, and liver homogenates. Many haloalkenes are metabolized to mercapturates, which also undergo acylase-catalyzed hydrolysis. The acylases that catalyze the deacetyl...

Background: Poly cystic ovarian syndrome (PCOS) is the most prevalent endocrinopathy among women and the most common underlying diagnosis for anovulatory infertility. The role of insulin-resistance (IR) and hyperinsulinemia in pathophysiology and clinical manifestations of the syndrome depicts the importance of evaluation of the efficacy of insulin reducing medications. N acetyl cysteine (NAC) ...

Background: Chronic obstructive pulmonary disease (COPD) affects various structural and functional domains in the lungs. It is characterized by damage of small airways due to an inflammatory process, oxidative stress and imbalance of proteolytic and anti-proteolytic activities. The aim of this work is to investigate the mechanisms involved in COPD and the role of erythromycin and/or N-acetyl cy...

Despite its proven cytotoxicity, poly-methyl methacrylate (PMMA) resin is one of the most frequently and extensively used materials in dental practice. This study hypothesized that an anti-oxidant amino acid, N-acetyl cysteine (NAC), has the potential to detoxify this material. Ten percent of the rat dental pulp cells were viable when cultured on the PMMA resin for 24 hours, while over 70% of t...

Swelling in an extremity, when confined by an unyielding constraint such as fascia, may result in impaired circulation in the limb as tissue pressure rises. In clinical practice, fasciotomy remains the only proven treatment of such a compartment syndrome (CS), however this is a procedure associated with significant morbidity and potential mortality. [1]. Establishing the diagnosis of compartmen...