phosphorus is an essential element for plants. much of the agricultural lands of iran has calcareous soils, in which, due to high ph, phosphorous availability is less, therefore, it appears as a limiting factor for plant growth. application of biofertilizers instead of chemical ones has gained attention in order to produce healthy crops, reduce pollution of soil and water resources by reducing ...

Dimethylarginine dimethylaminohydrolase (DDAH) is a key enzyme involved in the metabolism of asymmetric dimethylarginine (ADMA) and N-monomethyl arginine (NMMA), which are endogenous inhibitors of the nitric oxide synthase (NOS) family of enzymes. Two isoforms of DDAH have been identified in humans, DDAH-1 and DDAH-2. DDAH-1 inhibition represents a promising strategy to limit the overproduction...

Perampanel is an aryl substituted 2-pyridone AMPA receptor antagonist that was recently approved as a treatment for epilepsy. The drug potently inhibits AMPA receptor responses but the mode of block has not been characterized. Here the action of perampanel on AMPA receptors was investigated by whole-cell voltage-clamp recording in cultured rat hippocampal neurons. Perampanel caused a slow (τ∼1 ...

AIM To investigate the effects of huperzine A (Hup A) on NMDA receptors in rat cerebral cortex. METHODS 1) The effect of hup A on NMDA-induced current was studied in acutely dissociated rat hippocampal pyramidal neurons using whole-cell recording. 2) The effect of Hup A on NMDA receptor binding was assessed using [3H] dizocilpine (Diz) binding assay in synaptic membrane preparation of rat cer...

In this study, we investigated the hypothesis that inhibition of the N-methyl-D-aspartate (NMDA) receptor complex by zinc involves a polyamine-sensitive regulatory site. We found that the specific binding of the open channel ligand [3H]MK-801 to rat hippocampal membranes 1) was inhibited by low concentrations of Zn2+ (IC50 = 5.5 microM) by 65%. 2) This high-affinity component of inhibition was ...

A novel compound, ES-242-1, which binds to a site on N-methyl-D-aspartate (NMDA) receptor that is coupled to the channel domain, was isolated from the culture broth of a fungus, Verticillium sp. SPC-15898. ES-242-1 inhibited the [3H]thienyl cyclohexylpiperidine ([3H]TCP) binding to rat crude synaptic membrane fractions with an IC50 value of 116 nM, but did not inhibit the [3H]kainate binding to...

the leaf nitrogen content is generally accepted as an indicator of food quality and as a factor affecting host selection by phytophagous insects. the alate pea aphids (acyrthosiphon pisum harris, aphididae) were given a choice among non-nodulated pea plants (pisum sativum l.) supplied with one of four nitrate-n levels (0, 3, 15 and 30 mm). when whole plants were exposed to aphids for 7 days, th...

Anaerobic digestion is the breakdown of biodegradable organic material by microorganisms in the absence of oxygen or in an oxygen-starved environment.This technology is superior to the landfilling and also the aerobic composting. The aim of the present study was to examine whether the effluent Volatile Fatty Acids from the anaerobic acidogenesis of the food waste can be used du to its high valu...

Zinc inhibits NMDA receptor function through both voltage-dependent and voltage-independent mechanisms. In this report we have investigated the role that the NR1 subunit plays in voltage-independent Zn2+ inhibition. Our data show that inclusion of exon 5 into the NR1 subunit increases the IC50 for voltage-independent Zn2+ inhibition from 3-fold to 10-fold when full length exon 22 is also splice...