This study aimed to prepare a nanoemulsion vehicle improve the oral bioavailability of hesperetin. The pseudo-ternary phase diagrams and RSM were used optimize parameters. Compared with hesperetin suspension, AUC0-t Cmax increased by 5.67-fold 2.64-fold, respectively. proportion lymphatic transport reached 87.72%, cumulative absorption amount jejunum, ileum, duodenum 1.1-fold, 1.92-fold, 1.5-fo...