Objective: β3-adrenoceptor agonists (BARA) represent a novel mechanism of action for direct relaxation of urinary bladder smooth muscle. Myrbetriq (MYR) is an FDA approved BARA developed by Astellas Pharma, and has proven to be very useful for treating overactive bladder. Preliminary data from this laboratory demonstrated a remarkable effect of a rat-specific BARA, CL-316,243 (CL), on the hallm...

The economic efficiency of the National Fire Management Analysis System (NFMAS) and FIREPRO is examined. A brief history of the two programs is provided, as well as recent improvements to the contemporary theory of cost plus net value change (C+NVC). The NFMAS process is reviewed relative to the theory of C+NVC with particular focus on its ability to reliably locate the most efficient level (ME...

A one-step method was implemented to graft N-vinylcaprolactam (NVCL) and 4-vinylpyridine (4VP) onto silicone rubber (SR) films using gamma radiation in order to endow the silicone surface with temperature- and pH-responsiveness, and give it the ability to host and release diclofenac in a controlled manner and thus prevent bacterial adhesion. The effects of radiation conditions (e.g., dose and m...