Statoil has designed and tested dual diameter pipeline pigs to perform various tasks during operations, precommissioning and commissioning of the 710km 42"x28" Åsgard pipeline. The concepts developed have been put through a major design and testing program to demonstrate that the various functional requirements have been met. The paper describes the development process as well as field experien...

As they involve expectations about the future and long lead times for planning and construction, the evolution of investment projects is usually complex and volatile. This paper analyses an important aspect of this volatility by studying the nature of the investment process, from the initial bright idea to the final construction and operational phase of a project. We refer to this process as th...

Although there exist many high-performing text-mining tools to address literature biocuration (populating biomedical databases from the published literature), the challenge of delivering effective computational support for curation of large-scale biomedical databases is still unsolved. We describe a community-driven solution (the SciKnowMine Project) implemented using the Unstructured Informati...

Population scale sequencing of whole human genomes is becoming economically feasible; however, data management and analysis remains a formidable challenge for many research groups. Large sequencing studies, like the 1000 Genomes Project, have improved our understanding of human demography and the effect of rare genetic variation in disease. Variant calling on datasets of hundreds or thousands o...

The International Mouse Phenotyping Consortium (IMPC) plans to phenotype 20,000 single-gene knockout mice to gain an insight into gene function. Approximately 30% of these knockout mouse lines will be embryonic or perinatal lethal. The IMPC has selected threedimensional (3D) imaging to phenotype thesemouse lines at relevant stages of embryonic development in an attempt to discover the cause of ...

The Research and De®elopment Pipeline management problem has far-reaching economic implications for new-product-de®elopment-dri®en industries, such as pharmaceutical, biotechnology and agrochemical industries. Effecti®e decision-making is required with respect to portfolio selection and project task scheduling in the face of significant uncertainty and an e®er-constrained resource pool. The her...

In 2001, the Federal Office of Pipeline Safety promulgated its pipeline integrity management rule for hazardous liquid pipelines. A notice of proposed rule making for a similar rule for gas pipelines was issued in January 2003. A final rule must be in place by the end of 2003. These rules derive from formal risk management initiatives of both the pipeline industry and the regulators beginning i...

The International Mouse Phenotyping Consortium (IMPC) plans to phenotype 20,000 single-gene knockout mice to gain an insight into gene function. Approximately 30% of these knockout mouse lines will be embryonic or perinatal lethal. The IMPC has selected threedimensional (3D) imaging to phenotype thesemouse lines at relevant stages of embryonic development in an attempt to discover the cause of ...