LCH: Langerhans cell histiocytosis INTRODUCTION Langerhans cell histiocytosis (LCH) identifies a spectrum of disorders that are classified according to the organs involved (singleor multi-organ disease) and the presence or absence of organ failure. Patients younger than 2 years with a multisystem disease have a significantly higher mortality rate than older children. Nail involvement in LCH is ...

Fig. 2. Strong HMB-45 positivity of the tumour cells (×200). Sir, Subungual melanoma is a relatively rare disease with a reported incidence of between 0.7% to 3.5% of all melanoma cases in the general population (1). Most common sites of involvement are the big toe, the thumb and the index and ring fingers, respectively (2–4). Common signs include pigmentation of the nail bed, nail loss, and na...

Yellow nail syndrome (YNS) is characterized by the triad of nail changes, lymphedema and respiratory tract involvement. Several hypotheses have been postulated to explain the findings in YNS including lymphatic drainage abnormalities along with microvasculopathy. The most recent hypothesis, proposed by Berglund and Calmark [Biol Trace Elem Res 2011;143:1-7], suggests a role of titanium dioxide ...

Yellow nail syndrome (YNS) is characterized by the triad of nail changes, lymphedema and respiratory tract involvement. Several hypotheses have been postulated to explain the findings in YNS including lymphatic drainage abnormalities along with microvasculopathy. The most recent hypothesis, proposed by Berglund and Calmark [Biol Trace Elem Res 2011; 143: 1–7], suggests a role of titanium dioxid...

Yellow nail syndrome (YNS) is characterized by the triad of nail changes, lymphedema and respiratory tract involvement. Several hypotheses have been postulated to explain the findings in YNS including lymphatic drainage abnormalities along with microvasculopathy. The most recent hypothesis, proposed by Berglund and Calmark [Biol Trace Elem Res 2011; 143: 1–7], suggests a role of titanium dioxid...

Nail involvement is part of the clinical spectrum of psoriatic disease and is microanatomically associated with distal interphalangeal joint (DIPJ) entheses. Tumour necrosis factor (TNF) inhibitors have shown efficacy for psoriasis, arthritis, enthesitis, dactylitis and nail disease. Given the intimate links between psoriatic arthritis (PsA) and nail disease, it might be expected that nail dise...

Psoriasis is a chronic inflammatory scaling skin disorder affecting approximately 0.1~3.0% population. Nail and joint involvement are not uncommon in psoriatic patients. However, psoriatic onychopathy with an underlying bony/periosteal involvement in the distal phalanx is exceptionally rare. In our case, psoriasis with psoriatic nails and enlarged distal digits without evidence of joint involve...

Involvement of sensitive or challenging body areas is an important treatment consideration since patients with psoriasis in these can have disproportionately greater burden disease. We assess comprehensive clearance by measuring the ability ixekizumab to achieve complete skin (PASI 100) up 5 years when multiple (scalp, nails, palmoplantar [pp] regions) are involved. Data were integrated from UN...