The design principles of fluorescence-based siderophore sensor molecules for detection of heavy transition-metal (HTM) ions are first reviewed. As an example, fluorescein-desferrioxamine (FlDFO), a highly efficient fluorophore molecule combining a specific Fe ion receptor and a fluorescence-sensitive signalling site has been designed, synthesized, and used for dosing with Fe ions. Its response ...

Metal ions homeostasis plays an important role in biological processes. The ability to detect the concentration of metal fluids is often challenged by obvious interference or competitive binding nature other alkaline metals ions. Common analytical techniques employed for detection are electrochemical, fluorescence and colorimetric methods. However, most reported sensors complicated, time-consum...

This study focuses on discovering a new aptamer sequence that binds specifically and with high affinity to brain natriuretic peptide (BNP), which is indicative of the early stages of heart failure. A library of random DNA sequences was generated synthetically, amplified by the polymerase chain reaction (PCR) and evaluated for specific binding to BNP using an in vitro selection technique known a...

This paper reports the synthesis and fabrication of aligned electrospun nanofibers derived out of multiwalled carbon nanotubes (MWCNTs) embedded SU-8 photoresist, which are targeted towards ultrasensitive biosensor applications. The ultrasensitivity (detection in the range of fg/mL) and the specificity of these biosensors were achieved by complementing the inherent advantages of MWCNTs such as ...

A novel type of bioelectronic region ion sensitive field effect transistor (RISFET) nanosensor was constructed and demonstrated on two different sensor chips that could measure glucose with good linearity in the range of 0-0.6mM and 0-0.3mM with a limit of detection of 0.1 and 0.04 mM, respectively. The sensor is based on the principle of focusing charged reaction products with an electrical fi...

We present for the first time a complex network approach to the study of the electrical properties of single protein devices. In particular, we consider an electronic nanobiosensor based on a G-protein coupled receptor. By adopting a coarse grain description, the protein is modeled as a complex network of elementary impedances. The positions of the alpha-carbon atoms of each amino acid are take...