Nanoemulsions are feasible delivery systems of lipophilic compounds, showing potential as edible coatings with enhanced functional properties. The aim of this work was to study the effect of emulsifier type (stearic acid (SA), Tween 80 (T80) or Tween 80/Span 60 (T80/S60)) and emulsification process (homogenization, ultrasound or microfluidization) on nanoemulsion formation based on oxidized cor...

In this work, we examined enhanced skin delivery of minoxidil applied in nanoemulsions incorporating skin penetration enhancers. Aliquots of fully characterized oil-in-water nanoemulsions (1 mL), containing minoxidil (2%) and the skin penetration enhancer oleic acid or eucalyptol as oil phases, were applied to full-thickness excised human skin in Franz diffusion cells, while aqueous solutions (...

Inflammation is a common process associated with numerous vascular pathologies. We hypothesized that targeting the inflamed endothelium by coupling a peptide with high affinity for P-selectin to the surface of dexamethasone-loaded lipid nanoemulsions will highly increase their specific binding to activated endothelial cells (EC) and reduce the cell activation. We developed and characterized dex...

Thistle oil (INCI: Silybum marianum seed oil) is known as an anti-oxidant, moisturizing and skin regenerating cosmetic raw material. Nanoemulsions are a new form of cosmetic product showing very good user properties (ease of spreading over the skin with no greasy feeling). Moreover, due to their structure, they can also transport both hydrophilic and hydrophobic active substances to the skin. T...

Cationic lipids have been used in the development of non-viral gene delivery systems as lipoplexes. Stearylamine, a cationic lipid that presents a primary amine group when in solution, is able to compact genetic material by electrostatic interactions. In dispersed systems such as nanoemulsions this lipid anchors on the oil/water interface confering a positive charge to them. The aim of this wor...

Nanoemulsions have small droplet size and are kinetically stable colloidal systems. These the thermodynamically isotropic system in which two immiscible liquids mixed to form a single phase by means of appropriate surfactant cosurfactant. Nanoemulsion sizes fall typically range 20–200 nm shows narrow distribution. They enhanced functional properties comparison conventional emulsions. The compos...

Background : Medicine’s success relies on solubility, which is the process of dissolving a solid substance in fluid phase to create uniform molecular dispersion. However, hydrophobic active medicinal components exhibit poor solubility water, limiting their effectiveness and incorporation into medications. Aim This review explores potential nanoemulsions as solution for delivering with low solub...

Vegetable oils present important pharmacological properties, which gained ground in the pharmaceutical field. Its encapsulation in nanoemulsions is considered a promising strategy to facilitate the applicability of these natural compounds and to potentiate the actions. These formulations offer several advantages for topical and systemic delivery of cosmetic and pharmaceutical agents including c...

We demonstrate that the traditional emulsification theory can be enriched by a self-assembly approach, in which hydrophilic copolymers with one block exhibiting noncovalent forces with the oil phase self-assemble at the oil-water interface, thereby reducing interfacial tension and forming emulsions. This approach was established using affinity diblock copolymers that can interact with oil molec...

A new type of contrast agent for Xe NMR based on surfactant-stabilized perfluorocarbon-in-water nanoemulsions has been produced. The contrast agent uses dissolved hyperpolarized xenon gas as a nonperturbing reporting medium, as xenon freely exchanges between aqueous solution and the perfluorocarbon interior of the droplets, which are spectroscopically distinguishable and allow for chemical exch...