The architecture of an engineered tissue substitute plays an important role in modulating tissue growth. A novel poly(D,L-lactide-co-glycolide) (PLGA) structure with a unique architecture produced by an electrospinning process has been developed for tissue-engineering applications. Electrospinning is a process whereby ultra-fine fibers are formed in a high-voltage electrostatic field. The elect...

Periodontitis is a set of inflammatory conditions affecting the tissues surrounding teeth predominantly sustained by bacterial infections. The aim work was design and development scaffolds based on biopolymers to be inserted in periodontal pocket restore tissue integrity treat Nanofibrous were prepared means electrospinning. Gelatin considered as base component associated low high molecular wei...

Controlling the thickness of an electrospun nanofibrous scaffold by altering its pore size has been shown to regulate cell behaviors such as cell infiltration into a three-dimensional (3D) scaffold. This is of great importance when manufacturing tissue-engineering scaffolds using an electrospinning process. In this study, we report the development of a novel process whereby additional aluminum ...

A tissue-engineering scaffold resembling the structure of the natural extracellular matrix can often facilitate tissue regeneration. Nerve and tendon are oriented micro-scale tissue bundles. In this study, a method combining injection molding and thermally induced phase separation techniques is developed to create single- and multiple-channeled nanofibrous poly(L-lactic acid) scaffolds. The ove...

Abstract This study aims to produce composite nanofibers from polylactic acid (PLA) and silk fibroin (SF) with mechanical properties similar that of a native meniscus. SF is natural protein, well known for its good biocompatibility biodegradability but it has poor compared synthetic polymers. contains proteins which can promote cell adhesion proliferation required tissue engineering scaffold. P...

Background: Nano-scaffolds loaded with bioactive compounds such as ZnO nanoparticles (ZnO-NPs), tissue-engineered artificial skin grafts, can be a suitable substitute for extracellular matrix and greatly contribute to accelerating chronic wound treatment by decreasing the chance of bacterial infection. Methods: Silk fibroin nanofiber was fabricated using electrospinning three-dimensional porous...

INTRODUCTION The native inability of nervous system to regenerate, encourage researchers to consider neural tissue engineering as a potential treatment for spinal cord injuries. Considering the suitable characteristics of induced pluripotent stem cells (iPSCs) for tissue regeneration applications, in this study we investigated the adhesion, viability and proliferation of neural progenitors (der...

Aims: This study aimed to prepare and physicochemically evaluate as well assess the cytotoxicity stimulation of early osteogenic differentiation dental pulp stem cells gelatin-hydroxyapatite (Gel-HA) fibrous nanocomposite scaffold. Background: Recently, electrospinning approach in nanotechnology has been considered due its application preparation biomimetic nanofibers for tissue engineering. Ob...