A new route for the synthesis of functional aqueous nanogels decorated with a controlled amount of surface-drafted isoeugenol molecules has been developed. Obtained nanogels exhibit two key functions: a) antibacterial activity against different oral pathogens and b) cell-adhesive and -growth-promoting properties. Functional nanogels can be potentially used as building blocks in the design of bi...

Abstract Background In order to deliver bioactive compounds with better thermal stability and delayed release characteristics, nanogels can be placed inside a hydrogel network. The aim of the present study was develop isolated soy protein (ISP)–sodium alginate (SA) nanogel (NG) (0, 10, 15 20%)-based cress seed gum (CSG) as delivery system curcumin (Cur). A systematic performed describe rheologi...

The term “nanogel” refers to highly cross-linked hydrogels with a size between 20 and 200 nm. Due their tiny size, they have higher penetration greater drug-loading capacity. They release the medication using mechanisms such as photochemical internalization, volume transition, pH responsiveness, thermo sensitive, photo isomerization. can be categorized according whether respond stimuli or not w...

Self-assembled nanogels made of hydrophobized pullulan were obtained using a versatile, simple, reproducible and low-cost method. In a first reaction pullulan was modified with hydroxyethyl methacrylate or vinyl methacrylate, further modified in the second step with hydrophobic 1-hexadecanethiol, resulting as an amphiphilic material, which self-assembles in water via the hydrophobic interaction...

pH-Degradable PVA nanogels, which are prepared by photo-crosslinking thermo-preinduced PVA nanoaggregates in water without any surfactants or toxic organic solvents, are used for intracellular PTX release and anticancer treatment. These nanogels fast degraded at mildly acidic conditions with a pH-triggered PTX release, and the degradation products are only native PVA and poly(hydroxyethyl acryl...

Metals are essential in medicine for both therapy and diagnosis. We recently created the first metal-chelating nanogel imaging agent, which employed versatile, reproducible chemistry that maximizes chelation stability. Here we demonstrate that our metal chelating crosslinked nanogel technology is a powerful platform by incorporating (64)Cu to obtain PET radiotracers. Polyacrylamide-based nanoge...