BACKGROUND Over one hundred different pharmaceutical dosage forms have been recorded in literatures of Traditional Persian Medicine among which nasal forms are considerable. OBJECTIVES This study designed to derive the most often applied nasal dosage forms together with those brief clinical administrations. MATERIALS AND METHODS In the current study remaining pharmaceutical manuscripts of P...

INTRODUCTION Certain drugs are delivered to the nasal cavity because their intended site of action. These are administrated as nasal drops or sprays for a local effect. Such drugs in clinical use include decongestants, antibiotics and mucolytics. The nasal cavity may also be exploited as a route of entry into the systematic circulation, either because the absorption profile of the drug is appro...

Intranasal route is one of the most attractive routes for distributing drugs to systemic circulation. Liposomes are used as biocompatible carriers to improve delivery properties across nasal mucosa. The objective of the present study was to formulate acyclovir liposomes and partition into poly-N-vinyl-2-pyrrolidone. Entrapment efficiency showed that multilamellar and unilamellar liposomes were ...

In a double-blind group sequential trial the efficiency of an oxytocin nasal spray in enhancing lactation was studied during the first five days after delivery in women who had given birth prematurely. The cumulative volume of breast milk obtained between the second and fifth days after delivery was 3.5 times greater in primiparas given oxytocin than in primiparas given placebo. There was no si...

OBJECTIVES This study aimed to examine the feasibility of nasal powder formulations for the delivery of levodopa (L-dopa) into the brain using highly water-soluble levodopa methyl ester hydrochloride (LDME). METHODS For designing nasal LDME powders, pH-rate stabilities of LDME in buffer solutions and their enzymatic degradations in rabbit nasal mucosal and serosal extracts were investigated. ...