We propose a general theory of cooperativity between transmembrane receptors of a cell. Based on a conformation-dependent interaction between nearest-neighboring receptors, the sensitive signalling and the enhancement of clustering, or oligomerization, are explained as two responses to ligand binding. In this model, ligand binding shifts the energy difference between the two conformational stat...

Many real applications consume data that is intrinsically uncertain, noisy and error-prone. In this study, we investigate the problem of finding the top-k nearest neighbors in uncertain data series, which occur in several different domains. We formalize the top-k nearest neighbor problem for uncertain data series, and describe a model for uncertain data series that captures both uncertainty and...

Take N sites distributed randomly and uniformly on a smooth closed surface. We express the expected distance ŒDkN‘ from an arbitrary point on the surface to its kth-nearest neighboring site, in terms of the function Al‘ giving the area of a disc of radius l about that point. We then find two universalities. First, for a flat surface, where Al‘ = πl2, ŒDkN‘ is separable in k and N . All kt...

In this paper we present a new framework for emotion recognition from speech based on a similarity concept called Weighted Ordered Classes-Nearest Neighbors (WOC-NN). Unlike the k-nearest neighbor, an instance-similarity based method; WOC-NN computes similarities between a test instance and a class pattern of each emotion class. An emotion class pattern is a representation of its ranked neighbo...

Nearest-neighbor intermolecular distances of molecules adsorbed on the surface of nanocrystalline TiO(2) particles were evaluated by the electron spin resonance (ESR) technique with molecules having a nitroxide radical and a carboxyl group as a spin probe to clarify their aggregation behaviors on TiO(2) and the influence of coadsorbates.

By using a model Hamiltonian with d-wave superconductivity and competing antiferromagnetic (AF) orders, the local staggered magnetization distribution due to nonmagnetic impurities in cuprate superconductors is investigated. We show that the net moment induced by a single impurity corresponds to a local spin with S(z)=0 or 1/2 depending on the strength of the AF interaction U and the impurity s...

A number of approaches to computing nearest neighbor queries in Euclidean space are presented. This includes the depth-first and best-first methods as well as a comparison. The best first method is shown to be capable of being extended to report the neighboring objects in increasing order from the query object so that the search can be incremental and there is no need to know the value of k in ...

We study via Monte Carlo simulations the influence of elastic interactions on the ordering and decomposition of a two-dimensional model binary alloy with antiferromagnetic nearest and ferromagnetic next nearest neighbor type interactions following a quench into the coexistence region. The elastic interaction leads to the development of a platelet morphology for the segregated ordered and disord...

Single dye molecules incorporated into a mesoporous matrix can act as highly sensitive reporters of their environment. Here, we use single TDI molecules incorporated as guests into hexagonal mesoporous films containing highly structured domains. The dye molecules allow us to map the size of these domains which can extend to over 100 microm. Investigation of the translational and orientational d...

$n$-alkane/urea inclusion compounds are prototypical examples of aperiodic crystals with uniformly aligned alkane guest molecules contained within linear channels formed by the supramolecular urea host. Here, we investigate single-crystal diffuse scattering, which is present in form sharp layers, from short-chain (from octane to dodecane). The strong modulation scattering these layers shows tha...