The compound SB-612111 [(-)-cis-1-methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol] was recently identified as a selective antagonist for the nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP). In the present study, the in vitro pharmacological profile of SB-612111 at human recombinant NOP receptors expressed in Chinese hamster ovary (CHO) c...

The nociceptin receptor (NOP) and its ligand nociceptin/orphanin FQ (N/OFQ) have been shown to exert a modulatory effect on immune cells during sepsis. We evaluated the suitability of an experimental lipopolysaccharide (LPS)-induced sepsis model for studying changes in the nociceptin system. C57BL/6 mice BALB/c mice and Wistar rats were inoculated with different doses of LPS with or without a n...

This paper presents a distributed algorithm for discovering multiple shortest paths in an ad hoc network from a source s to a destination d. For each neighbor x of s which lies on a loop-free sd -path, we find one shortest sd -path via node x. The algorithm requires only O(N) many messages.

(Author) A. self-administered questionnaire was used to'compare Tselected driving, personality, and psychosocial variables 'of 306 convicted male drunk drivers with those of 289 alcoholics and 269 controls. She drunk driver group fell between the other,groups on many parameters but resembled the control groUp on as many others. While some 40% of the drunk drivers appeareA to be alcoholics, they...

Recently, a fully-integrated embedded system becomes popular for portable devices due to the cost reduction and the low-power operation. To reduce the size of the imbedded program, some hardware techniques such as nop-beforeexecution and programmable-delay-slot are introduced in CoreA embedded processor [1]. However, the previous designs using Core-A processor are not user-friendly due to the a...

Nociceptin/orphanin FQ (N/OFQ) antinociception, which is mediated selectively by the N/OFQ peptide receptor (NOP), was demonstrated in pain models. In this study, we determine the role of activated microglia on the analgesic effects of N/OFQ in a rat model of neuropathic pain induced by chronic constriction injury (CCI) to the sciatic nerve. Repeated 7-day administration of minocycline (30 mg/k...

One of the most important and challenging issues in real-time applications of resource-constrained wireless sensor networks (WSNs) is providing end-to-end delay requirement. To address such an issue a few QoS routing protocols have been proposed. THVR (Two-Hop Velocity based routing protocol) is newly proposed real-time protocol while it is based on the concept of using two-hop neighbor informa...

We consider discrete-time nearest-neighbor quantum walks on random environments in one dimension. Using the method based on a path counting, we present both quenched and annealed weak limit theorems for the quantum walk.

Cebranopadol (trans-69-fluoro-49,99-dihydro-N,N-dimethyl-4-phenylspiro[cyclohexane-1,19(39H)-pyrano[3,4-b]indol]-4-amine) is a novel analgesic nociceptin/orphanin FQ peptide (NOP) and opioid receptor agonist [Ki (nM)/EC50 (nM)/relative efficacy (%): human NOP receptor 0.9/13.0/89; human mu-opioid peptide (MOP) receptor 0.7/1.2/104; human kappa-opioid peptide receptor 2.6/17/67; human delta-opio...

The excellent pharmacological profile displayed by the selective nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor antagonist SB-612111 [(-)-cis-1-methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol] in vitro prompted us to investigate the actions of this compound in vivo. In the mouse tail withdrawal assay, SB-612111 given i.p. up to 3 mg/kg ...