Thrombosis is a life-threatening complication of hemolytic anemia in humans. Cardiac thrombi are present in all adult alpha-spectrin-deficient (sph/sph) mice with severe hereditary spherocytosis, providing a model for events preceding thrombosis. The current study evaluated (1) the timing of thrombosis initiation and (2) the effect of postnatal transplantation of normal cells on life span and t...

OBJECTIVE To evaluate umbilical cord abnormalities predisposing to mechanical cord compression and determine their relationship to adverse clinical outcomes and stasis-associated histologic changes in the placenta. METHODS Placental slides of 224 singleton pregnancies with gross cord abnormality (true knots, long cords, nuchal/body cords, abnormal cord insertion, hypercoiled cords, narrow cor...

Thrombosis is a life-threatening complication of hemolytic anemia in humans. Cardiac thrombi are present in all adult a-spectrin–deficient (sph/sph) mice with severe hereditary spherocytosis, providing a model for events preceding thrombosis. The current study evaluated (1) the timing of thrombosis initiation and (2) the effect of postnatal transplantation of normal cells on life span and throm...

Gangrene of a limb presenting at birth is rare and has heterogenous etiology. Approximately 25% of the cases have been reported to occur in infants of diabetic mothers (IDMs). We report a newborn IDM with brachial artery thrombosis in utero and neonatal gangrene which necessitated a below elbow amputation at 5th day of life. The diagnosis of external left brachial artery thrombosis was made by ...

Renal artery thrombosis and ischaemia presenting as severe neonatal hypertension A baby boy (1460 g) was delivered at 30 weeks' gestation by caesarean section for preterm labour and fetal distress. Umbilical arterial and venous catheters were inserted between T8 and T9 briefly during the immediate postnatal period. On day 23, the baby was hypertensive (highest blood pressure 113/77 mm Hg; mean ...

Introduction: cerebral vein thrombosis is a rare complication of nephrotic syndrome (NS).We report a known case of NS with hemorrhagic thrombosis. Case report: A boy with previous history of NS was admitted with headache and decrease of level of consciousness and his brain images were revealed hemorrhagic thrombosis Conclusions: cerebral vein thrombosis must be considered in patients with...

Umbilical vessel catheterization is a common procedure in Neonatal Intensive Care Units, especially in very low birthweight infants. Rarely, umbilical artery catheters break, and the retained fragments can cause thrombosis, infection, distal embolization, and even death. Herein, we describe a neonate with clinically significant bilateral limb ischemia developing after removal of a broken umbili...

Portal vein thrombosis (PVT) is a rare condition in the general population that develops serious complications if left untreated for long time. We present case of 29-year-old woman who developed PVT due to protein S deficiency versus neonatal funiculitis. Over time, patient upper gastrointestinal bleeding esophageal varices and hypersplenism with splenic sequestration caused minor episodes. Lap...