distal renal tubular acidosis is a syndrome of abnormal urine acidification and is characterized by hyperchloremic metabolic acidosis, hypokalemia, hypercalciurea, nephrocalcinosis and nephrolithiasis. despite the presence of persistent hypokalemia, acute muscular paralysis is rarely encountered in males.here, we will report an eighteen year old male patient who presented with flaccid quadripar...

1. The association of varying levels of urinary pH, urinary citrate and urinary calcium and magnesium excretion rates with kidney citrate, calcium and magnesium concentrations in experimental nephrocalcinosis was examined in twenty-four rats in a 3 x 2 multifactorial experiment with four replicates. All rats received the same synthetic diet for 6 weeks before being killed in the seventh week. I...

Abstract Background and Aims Multiple Endocrince Neoplasia type 1 (MEN1) syndrome, has an autosomal dominant transmission pattern, characterized by hyperparathyroidism, benign or malignant tumors in pancreas islets, pituitary tumors, thymic carcinomas, adrenal cortex adenomas angio-fibromas of the skin. We are describing 2 cases MEN1 with first cardinal manifestations within kidney. Method Medi...

Prevalence of hypercalciuria is markedly increased in patients with calcium kidney stones, and recently it has been demonstrated that the risk to produce stones is positively related with the levels of calcium excretion in general population. The stonepromoting effect of hypercalciuria depends on the unusually high calcium concentrations in urine and tubular fluid, which favor calcium salt prec...

Although foscarnet was withdrawn at that nephrotoxicity; polyneuritis; renal failure time, haemodialysis was required 1 month later. Blood tests excluded an immune disorder. Renal ultrasono-graphy images were suggestive of nephrocalcinosis and biopsy revealed crystals (refringent on polarized micro

The hypercalcaemia in association with trisomy 21 (Down's syndrome) is often not recognised and therefore underdiagnosed. Patients present the tetrad of hypercalcaemia, Down’s syndrome, renal impairment, nephrocalcinosis. 1-3 
 A 30-month old child syndrome had a long history nonspecific symptoms, constipation feeding difficulties. He was on excessive bottle feeds, taking 14 bottles daily,...

BACKGROUND Familial hypomagnesaemia with hypercalciuria and nephrocalcinosis (FHHNC) is an autosomal recessive disorder of renal calcium and magnesium wasting frequently complicated by progressive chronic renal failure in childhood or adolescence. METHODS A 7 year old boy was investigated following the findings of marked renal insufficiency and nephrocalcinosis in his 18-month old sister. He ...