In ?Selective Growth Stimulating Effects of Mouse Sarcoma on the Sensory and Sympathetic Nervous System of the Chick Embryo,? Rita Levi-Montalcini [5] and Viktor Hamburger [6] explored the effects of two nerve growth stimulating tumors; mouse [7] sarcomas 180 and 37. This experiment led to the discovery that nerve growth factor [8] was a diffusible chemical and later to discoveries that the com...

Nerve growth factor is a neurotrophin that promotes cell growth, differentiation, survival and death through two different receptors: TrkA(NTR) and p75(NTR). Nerve growth factor serum concentrations increase during many inflammatory and autoimmune diseases, glomerulonephritis, chronic kidney disease, end-stage renal disease and, particularly, in renal transplant. Considering that nerve growth f...

The chemical and biological properties of the nerve growth factor isolated from Naja naja venom are described. The nerve growth promoting activity appears to be distinct from the most commonly known enzymes and toxins present in the venom. The purified nerve growth factor from cobra venom has properties remarkably similar to those of the nerve growth factor isolated from mouse submaxillary glan...

In ?Selective Growth Stimulating Effects of Mouse Sarcoma on the Sensory and Sympathetic Nervous System of the Chick Embryo,? Rita Levi-Montalcini [5] and Viktor Hamburger [6] explored the effects of two nerve growth stimulating tumors; mouse [7] sarcomas 180 and 37. This experiment led to the discovery that nerve growth factor [8] was a diffusible chemical and later to discoveries that the com...

Our previous study showed that systemic administration of the traditional Chinese medicine Epimedium extract promotes peripheral nerve regeneration. Here, we sought to explore the therapeutic effects of local administration of icariin, a major component of Epimedium extract, on peripheral nerve regeneration. A poly(lactic-co-glycolic acid) biological conduit sleeve was used to bridge a 5 mm rig...

Background and Objectives:Myocardial infarction (MI) elicits nerve sprouting. However, the time course and spatial distribution of this nerve sprouting and its relationship to the expression of neurotrophic factors is unclear. The aim of this study was to identify the association of nerve sprouting with the expression of neurotrophic factors. Materials and Methods:We induced MI in FVB mice by l...

Incubation of cell-free extracts from PC12 cells with [32P]ATP leads to the phosphorylation of a 100,000-dalton protein. In extracts from cells treated with nerve growth factor, the labeling of the 100,000-dalton protein is substantially and selectively reduced. Direct quantitation indicates that the reduction is a minimum of 30-50% in the various experiments. The decrease is evident after as l...