Down syndrome (DS) is the leading chromosomal cause of intellectual disability, yet the neural substrates of learning and memory deficits remain poorly understood. Here, we interrogate neural networks linked to learning and memory in a well-characterized model of DS, the Ts65Dn mouse. We report that Ts65Dn mice exhibit exploratory behavior that is not different from littermate wild-type (WT) co...

BACKGROUND The manifestation of major depressive disorder (MDD) may include cognitive symptoms that can precede the onset of MDD and persist beyond the resolution of acute depressive episodes. However, little is known about how cognitive symptoms are experienced by MDD patients and the people around them. METHODS In this international (Brazil, Canada, China, France, and Germany) ethnographic ...

Individuals who have sustained a mild brain injury (e.g., mild traumatic brain injury or mild cerebrovascular stroke) are at risk to show persistent cognitive symptoms (attention and memory) after the acute postinjury phase. Although studies have shown that those patients perform normally on neuropsychological tests, cognitive symptoms remain present, and there is a need for more precise diagno...

Although the cognitive symptoms of multiple sclerosis (MS) were acknowledged in the 1800s, until the latter part of the 20th century, these symptoms were poorly recognized. Cognitive impairment associated with MS has a profound impact on many aspects of daily life, including employment, academic life, and social functioning. The cognitive reserve can be protected in MS patients to a certain lim...

Cognitive deficits in schizophrenia are critically important predictors of long-term psychosocial outcome and are not significantly ameliorated by currently available medications. Cognitive remediation training has shown promise for alleviating cognitive symptoms of schizophrenia, but the clinical significance has often been limited by small effect sizes. Approaches that achieve larger improvem...

Historically the putamen has been known to have a key role in regulating motor function. However in recent years the importance of this nucleus in cognitive functions has become more understood, with a rough dorso-ventral distribution of function being described by several studies. Additionally the importance of the putamen as a key site of anti-psychotic action, inhibiting the uptake of dopami...

AIM OF THE STUDY To compare fibromyalgia prevalence in premenopausal and postmenopausal women and its relation to the climacteric symptoms. MATERIAL AND METHODS Two hundred and nine women were studied, who attended the gynecology consultation at the hospital. They were divided in two groups: group I (premenopausal, n = 113) and group II (postmenopausal, n = 96). In all of them, climacteric sy...

Alzheimer’s disease (AD) is a disabling neurodegenerative disorder typical of old age. Recent advances led to the development of drugs which effectively alleviate cognitive symptoms. About one-third of patients however do not respond to current pharmacological treatment (Ryu et al., 2005). Reasons of such lack of efficacy of available drugs may represent a step ahead in the understanding of thi...

Less than half of older adults with depression achieve remission with antidepressant medications, and rates of remission are even poorer for those with comorbid conditions. Psychosocial interventions have been effective in treating geriatric depression, either alone or better yet, in combination with antidepressant medications. Traditional strategies for nonpharmacological treatment of late-lif...

OBJECTIVES Previous investigations have presented some evidence of late cognitive effects in dental personnel exposed to metallic mercury. We wanted to examine if Norwegian dentists have an increased prevalence of symptoms consistent with neurological and/or cognitive malfunction. METHODS The study group consisted of 406 dentists from central Norway and 217 controls from the general populatio...