The National Toxicology Program (NTP) Center for the Evaluation of Risks to Human Reproduction (CERHR) conducted an evaluation of the potential for amphetamines to cause adverse effects on reproduction and development in humans. Amphetamines evaluated were D- and D,L-amphetamine and methamphetamine. Amphetamine is approved by the U.S. Food and Drug Administration for the treatment of attention ...

Abstract   Zinc is one of the  essential elements of body which has an important role in natural growth, development, and many biological performances. Zinc deficiency is a major health problem and pregnant women are at high risk. 82% of pregnant women worldwide suffer from zinc deficiency. Zinc deficiency during pregnancy has dangerous and irreparable effects such as growth impairment, spontan...

Methylmercury (MeHg) is an environmental pollutant known to cause neurobehavioral defects and is especially toxic to the developing brain. With recent studies showing that fetal exposure to low-dose MeHg causes developmental abnormalities, it is therefore important to find ways to combat its effects as well as to clarify the mechanism(s) underlying MeHg toxicity. In the present study, the effec...

Acetaminophen is a non-steroidal drug used as an anti-inflammatory, analgesic and antipyretic in humans animals. In chicks, neurotoxicity associated with acetaminophen has not been fully elucidated. The aim of this study was to identify the neurobehavioral, biochemical histopathological effects 7 day-old broiler chicks. acute LD50 estimated by up- and- down method, then influence on open field ...

objective: neurocognitive deficits are now recognized as part of the fundamental disturbances and are a major determinant of functional outcome in psychosis. a cross-sectional association between cognitive deficits and poor social and occupational outcomes has been demonstrated; and treatment of cognitive impairment at the time of the first episode may have the potential to change functional ou...

Pfiesteria piscicida Steidinger & Burkholder, an estuarine dinoflagellate known to kill fish, has also been associated with neurocognitive deficits in humans. We have developed a rat model to determine the cause-and-effect relationship between exposure to Pfiesteria-containing water and cognitive impairment and to determine the neurobehavioral mechanisms underlying the Pfiesteria effect. The ra...

A large and growing body of literature is available on the neurotoxicity of methylmercury and PCBs as expressed in the behavior of both humans and laboratory animals. Methylmercury and PCBs will be compared with PCBs with attention directed at overlaps and distinctions in their profiles of neurotoxicity. It is possible with methylmercury and, to a lesser extent, with PCBs to characterize the se...