نتایج جستجو برای: neurogenic inflammation

تعداد نتایج: 180208  

2014
Camilla Fusi Serena Materazzi Silvia Benemei Elisabetta Coppi Gabriela Trevisan Ilaria M. Marone Daiana Minocci Francesco De Logu Tiziano Tuccinardi Maria Rosaria Di Tommaso Tommaso Susini Gloriano Moneti Giuseppe Pieraccini Pierangelo Geppetti Romina Nassini

Use of aromatase inhibitors (AIs), exemestane, letrozole and anastrozole, for breast cancer therapy is associated with severe pain symptoms, the underlying mechanism of which is unknown. The electrophilic nature of AIs suggests that they may target the transient receptor potential ankyrin 1 (TRPA1) channel, a major pathway in pain transmission and neurogenic inflammation. AIs evoke TRPA1-mediat...

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