human umbilical cord matrix (hucm) is considered as a promising source of mesenchymal stem cells (mscs) due to several advantages over other tissues. the potential of neural differentiation of hucm-mscs is of great interest in the context of treating neurodegenerative diseases. in recent years, considerable efforts have been made to establish in vitro conditions for improving the differentiatio...

Neuron-specific enolase (EC 4.2.1.11; NSE), a glycolytic enzyme produced by neuronal and neuroendocrine cells, is used as a tumor marker of neuroendocrine cancers, especially small-cell lung cancer. We have evaluated the behavior of NSE in nonmalignant liver diseases in 161 patients who underwent a thorough clinical and biochemical evaluation. Nine of the 161 patients (5.6%)--three of the 86 ci...

The article by Ravibabu, et al, 1 provides important new data in the field of biomarkers to monitor exposures to lead within the workplace, as in the lead acid battery manufacturing. They found that the serum neuron-specific enolase (NSE) levels are not elevated in association with concentrations of blood lead levels among workers in the lead acid battery manufacturing plant. In our (unpublishe...

Sheagren JN, Hinshaw LB, The Veterans Administration Systemic Sepsis Cooperative Study Group: Impact of encephalopathy on mortality in the sepsis syndrome. Crit Care Med 1990; 18:801–6 4. Jackson AC, Gilbert JJ, Young GB, Bolton CF: The encephalopathy of sepsis. Can J Neurol Sci 1985; 12:303–7 5. Persson L, Hardemark HG, Gustafsson J, Rundstrom G, MendelHartvig I, Esscher T, Pahlmann S: S-100 p...

Spinal Cord Injury (SCI) is a debilitating condition characterized by damage to the spinal cord, resulting in loss of function, mobility, and sensation. Although increasingly prevalent US, no FDA-approved therapy exists due unfortunate complexity condition, difficulties SCI may be furthered development SCI-related complications, such as osteoporosis. demonstrates two crucial stages for consider...

Abstract Background Biological markers of acute nerve cell damage can assist in the outcome ischemic stroke, such as neuron-specific enolase (NSE) that have been tested for association with initial severity extent infarction, and functional outcome. Objective To determine short-term prognostic value biochemical marker stroke. Methods A cohort study carried out on 37 patients Data were gathered ...

Desmoplastic small round cell tumor (DSCRT) is a rare variant of sarcoma with a highly aggressive behavior. It usually affects abdominal cavity and has a male predominance. Its correct diagnosis and treatment is sophisticated and requires an experienced multidisciplinary team. Hereby we present a 25 yrold man from Kerman Province in 2013 with abdominal mass and ascites who underwent sonograghy ...

The most examined tumor markers in lung cancer patients are CEA, hormonal peptides, and some neurogenic enzymes in small cell carcinoma. Calcitonin, ACTH, ADH, CEA, neurophysin, oxytocin, beta-endorphin, neuron-specific enolase, and CK BB are elevated in serum specimens in 25-75% of cases of small cell carcinoma. The level of these markers is related to the stage of the disease in groups of pat...

Secretion of the neuroendocrine marker neuron-specific enolase by 24 pituitary tumours was measured in maintenance tissue culture. Eleven endocrine-active and 13 "functionless" tumours were defined by measurement of prolactin, growth hormone, luteinising hormone (LH) and follicle stimulating hormone (FSH) secretion rates in vitro and the corresponding plasma hormone levels. Measurement of prola...

were compared with each other regarding histological grade and immunoreactivity for p53 protein, neuron specific enolase and c-erbB-2 protein. Significantly more specimens expressed a high malignancy grade when the tumour had become hormone resistant than at the time of initial diagnosis (Gleason P:<0.0001, WHO P:0.0003). p53 protein immunoreactivity increased significantly with disease progres...