نتایج جستجو برای: neuronal calcium sensor
تعداد نتایج: 465421 فیلتر نتایج به سال:
In the brain, neuronal activation triggers an increase in cerebral blood flow (CBF). Here, we use two animal models and several techniques (two-photon imaging of CBF and neuronal calcium dynamics, intracellular and extracellular recordings, local pharmacology) to analyze the relationship between neuronal activity and local CBF during odor stimulation in the rodent olfactory bulb. Application of...
Wireless Sensor Networks are utilized for collecting physical information from a distant place by using sensing devices called sensors. In order to collect information more efficiently, wireless sensor networks (WSNs) are partitioned into clusters. This approach is an effective way to prolong the lifetime of WSNs. While using clustering approach the major concern is the choice of a suitable clu...
Visinin-like protein-1 (VILIP-1) belongs to the family of neuronal calcium sensor (NCS) proteins, a neuronal subfamily of EF-hand [corrected] calcium-binding proteins that are myristoylated at their N termini. NCS proteins are discussed to play roles in calcium-dependent signal transduction of physiological and pathological processes in the CNS. The calcium-dependent membrane association, the s...
Introduction: The functional effects of orexin-B on the calcium spikes and excitability of the neuronal soma membrane of garden snail, Helix aspersa were studied. Methods: Conventional intracellular recording, under the current clamp conditions was performed to examine the effects of orexin-B on the configuration and electrophysiological properties of calcium spikes. Results: Application o...
Calcium signaling controls many key processes in neurons, including gene expression, axon guidance, and synaptic plasticity. In contrast to calcium influx through voltage- or neurotransmitter-gated channels, regulatory pathways that control store-operated calcium entry (SOCE) in neurons are poorly understood. Here, we report a transcriptional control of Stim1 (stromal interaction molecule 1) ge...
Genetically encoded calcium indicators (GECIs) are mainly represented by two- or one-fluorophore-based sensors. One type of two-fluorophore-based sensor, carrying Opsanus troponin C (TnC) as the Ca2+-binding moiety, has two binding sites for calcium ions, providing a linear response to calcium ions. One-fluorophore-based sensors have four Ca2+-binding sites but are better suited for in vivo exp...
Modulation of G protein-coupled receptor (GPCR) signaling by local changes in intracellular calcium concentration is an established function of Calmodulin (CaM) which is known to interact with many GPCRs. Less is known about the functional role of the closely related neuronal EF-hand Ca(2+)-sensor proteins that frequently associate with CaM targets with different functional outcome. In the pres...
REGULATION OF NEURONAL EXCITABILITY: NEW MECHANISMS FOR SLOWAFTERHYPERPOLARIZATION ACTIVATION AND MODULATIONbyCLAUDIO A. VILLALOBOSDecember 2010 Advisor: Rodrigo Andrade, PhD.Major: PharmacologyDegree: Doctor of PhilosophyOne of the most characteristic features of pyramidal cells in the prefrontal cortex(PFC) is that they present a slow afterhyperpolarizing curre...
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