Two to three decades ago, systemic therapy for cancer was largely confined the use of cytotoxic chemotherapy, with endocrine breast and prostate being main exception. Since then, many other classes in both haematological solid cancers have been developed, including monoclonal antibodies, targeted pathway inhibitors, anti-angiogenics immunotherapy. The increasing number specificity new drugs pos...

triple negative breast cancers (tnbcs) are associated with aggressive course, higher rates of visceral and central nervous system metastases and lower survival rate than hormone receptor positive. once metastasis has occurred, a median survival was approximately one year. currently, chemotherapy in tnbc is similar to other her2- negative breast cancers but in the near future, it will revolution...

the application of chemotherapy in cancer treatment has been limited due to cause side effects such as toxicity against normal cells and drug resistance. in recent years, numerous studies have been focused on using natural products with chemotherapeutic drugs to enhance therapeutic efficiency and reduce cytotoxicity. on the other hand, encapsulation of drugs into nanoparticles (nps) can improve...