Piuvimii. , PHILIP J., JENNIFER M. H. LOGGIE AND THOMAS E. G m EY: A comparison of the cardiovascular effects of biogenic amines and their precursors in newborn and adult dogs. J. Pharmacol. Exp. Ther. 166: 293-298, 1969. There is relatively little information regarding the cardiovascular effects of the biogenic amines in newborn animals. In the present study the pressor and chronotropic respon...

To examine the effects of intrauterine growth restriction and acute severe oxygen deprivation on renal blood flow (RBF), renovascular resistance (RVR), and renal excretory functions in newborns, studies were conducted on 1-day-old anesthetized piglets divided into groups of normal weight (NW, n = 14) and intrauterine growth-restricted (IUGR, n = 14) animals. Physiological parameters, RBF, RVR, ...

Sleep deprivation impairs hippocampal-dependent learning, which, in turn, is associated with increased survival of newborn cells in the hippocampus. We tested whether the deleterious effects of sleep restriction on hippocampus-dependent memory were associated with reduced cell survival in the hippocampus. We show that sleep restriction impaired hippocampus-dependent learning and abolished learn...

OYAMA, JIRO, AND WILLTAM T. PLATT. Reproduction and growth of mice and rats under condz’tions of simulated increased gravity. Am. J* Physiol. ZIQ(I): 164-166. q67.-Mating studies were performed on rats and mice subjected to chronic centrifugation at various g loads. Rats conceived and delivered viable pups at 2.5 and 3.6 g but not at 4.7 g. Newborn pups, however, survived only when they were re...

This study examines the role of phosphate metabolites in the regulation of mitochondrial oxygen consumption of the heart in vivo as a function of development. We used an open chest lamb/sheep preparation in which myocardial oxygen consumption (MVO2) was monitored via an extracorporeal shunt from the coronary sinus. Phosphate metabolites were monitored simultaneously using 31P nuclear magnetic r...

Exogenous or inhaled NO (iNO) has been successfully used, as a selective pulmonary vasodilator, in a wide variety of clinical situations especially in the management of persistent pulmonary hypertension in the newborn. A better understanding of the role of endogenous and exogenous NO in the lungs of surfactant-deficient animals exposed to hyperoxia could result in novel strategies for the bette...

The toxicities of 4-nitrophenol and 2,4-dinitrophenol in newborn and young rats was examined and the susceptibility of newborn rats was analyzed in terms of presumed unequivocally toxic and no observed adverse effect levels (NOAELs). In the 18-day repeated dose newborn rat study, 4-nitrophenol was orally given from Day 4 to Day 21 after birth but did not induce any toxicity up to 160 mg/kg in t...

Neurogenesis impairment is associated with the chronic phase of the epilepsy in humans and also observed in animal models. Recent studies with animal models have shown that physical exercise is capable of improving neurogenesis in adult subjects, alleviating cognitive impairment and depression. Here, we show that there is a reduction in the generation of newborn granule cells in the dentate gyr...

B-cell-deficient mice were prepared by administration of rabbit anti-mouse-mu antiserum to newborn animals within 12 h of birth onwards. Such immunodeficient animals, along with the normal controls, were infected intravenously with Cryptococcus neoformans. There was no difference in the mortality pattern, viable count of cryptococci in different organs, delayed-type hypersensitivity reaction, a...

A simple program of handling and care of pregnant rats before delivery makes it possible to carry out surgical procedures on newborn pups without resultant cannibalism or rejection of the operated animals by their mothers.