Objective(s): The study is aimed to elucidate the impact of antioxidant, anti-inflammatory and antifibrosis properties of Lactobacillus acidophilus (L. acidophilus) on liver and colon in ethephon treated rats through measuring Pro- inflammatory cytokines, oxidative stress index, lysosomal cathepsin-D enzyme activity and fibrosis markers.Materials and ...

Objective(s):Therapies with high levels of oxygen are commonly used in the management of critical care. However, prolonged exposure to hyperoxia can cause acute lung injury. Although oxidative stress and inflammation are purported to play an important role in the pathogenesis of acute lung injury, the exact mechanisms are still less known in the hyperoxic acute lung injury (HALI).   Materials ...

The widely used immunosuppressant cyclosporine A (CSA) blocks nuclear translocation of the transcription factor, NF-AT (nuclear factor of activated T cells), preventing its activity. mRNA for several NF-AT isoforms has been shown to exist in cells outside of the immune system, suggesting a possible mechanism for side effects associated with CSA treatment. In this study, we demonstrate that CSA ...

FeNi-based hybrid materials are among the most representative catalysts for alkaline oxygen evolution reaction (OER), but modulation of their surface atoms to achieve optimal catalytic properties is still a big challenge. Here, we report modification Ni(OH)2/nickel foam (NF)-based electrocatalyst with trace amount ferrocene formic acid (FFA) (FFA-Ni(OH)2/NF) highly efficient OER. Owing strong e...

Controlling the cation to anion (Mn2+/MnO4−) molar ratios of precursors was used obtain a highly performance capacitive properties nanostructural MnO2 hybridized carbon-based materials on nickel foam (NF) through successive ionic layer adsorption and reaction technology. SEM, XRD, BET, XPS analyses are utilized investigate influence cation/anion as-obtained electrode materials. At lower ratio 1...

Monoclonal antibodies (mAbs) to rat neurofilament (NF) proteins NF-L, NF-M, and NF-H were used to examine the developmental programs of NF expression in rat embryos. The ability of these mAbs to recognize differentially phosphorylated states of NF-M and NF-H (Lee et al., 1987, the preceding paper) was exploited in order to examine the temporal and spatial patterns of NF phosphorylation during e...

Curcumin is active component of turmeric and isolated from the rhizome of turmeric, a phenolic natural product. One of inflammatory disease is multiple sclerosis, a multifocal chronic autoimmune inflammatory disease of the CNS, which is also known as a perivascular demyelinating disease. Studies have been shown that neuro-inflammation can have both harmful and beneficial effects on the neuronal...

NF-κB signaling is essential to an effective innate and adaptive immune response. Many immune-specific functional developmental outcomes depend in large on NF-κB. The formidable task of sorting out the mechanisms behind regulation outcome remains important area immunology research. Here we briefly discuss role regulating cell fate decisions at various times path B development, activation, gener...

Anion modification and trace metal doping have been widely demonstrated to unique advantages in regulating both electrocatalytic activity the electronic structure of non-precious materials. Developing a simple practical preparation strategy is critical, but it still faces challenges. In this paper, novel type dual-modification approach put forward rationally design S, Pt-CoNi material, which ca...

Nuclear factor-kappaB (NF-kappaB) regulates many genes involved in renal pathophysiologic processes. It was previously demonstrated that angiotensin II (AngII) and its amino-terminal degradation product AngIII activate NF-kappaB in mesangial cells. However, which are the Ang receptor subtypes involved in the NF-kappaB pathway and whether these Ang peptides act through the same or different rece...