The chimeric anti-CD20 antibody rituximab (Rituxan, IDECC2B8) is widely used in the clinical treatment of patients with non-Hodgkin’s lymphoma (NHL). Rituximab sensitizes NHL B-cell lines to drug-induced apoptosis via down-regulation of Bcl-xL expression. We hypothesized that the mechanism by which rituximab down-regulates Bcl-xL may be, in part, due to inhibition of constitutive nuclear factor...

Background. Nuclear factor-kB (NF-kB) regulates genes involved in renal disease progression, such as the chemokines monocyte chemoattractant protein-1 (MCP-1) and RANTES. NF-kB is activated in experimental models of renal injury, and in vitro studies also suggest that proteinuria and angiotensin II could be important NF-kB activators. It has been proposed that locally produced MCP-1 may be invo...

Epidemiologic studies suggest that diet rich in plantderived foods plays an important role in the prevention of prostate cancer. Curcumin, the yellow pigment in the spice turmeric, has been shown to exhibit chemopreventive and growth inhibitory activities against multiple tumor cell lines. We have shown previously that curcumin and tumor necrosis factor–related apoptosis-inducing ligand (TRAIL)...

Type 2 diabetes (T2D) is associated with vascular dysfunction. We hypothesized that increased nuclear factor-kB (NF-kB) signaling contributes to vascular dysfunction in T2D. We treated type 2 diabetic (db/db) and control (db/db) mice with two NF-kB inhibitors (6 mg/kg dehydroxymethylepoxyquinomicin twice a week and 500 mg/kg/day IKK-NBD peptide) for 4 weeks. Pressure-induced myogenic tone was s...

Schroeder, Rebecca A., Charles Cai, and Paul C. Kuo. Endotoxin-mediated nitric oxide synthesis inhibits IL-1b gene transcription in ANA-1 murine macrophages. Am. J. Physiol. 277 (Cell Physiol. 46): C523–C530, 1999.—On the basis of previous work demonstrating nitric oxide (NO)mediated inhibition of nuclear factor-kB (NF-kB) DNA binding, we hypothesized that NO downregulates NF-kB-dependent inter...

Vessel injury results in the elaboration of various cytokines, including tumor necrosis factor-a (TNF-a), which may influence vascular smooth muscle cell (VSMC) function and contribute to atherogenesis. We tested the hypothesis that TNF-a–induced VSMC proliferation requires activation of the transcription factor nuclear factor-kB (NF-kB), which could be prevented by delivery of the NF-kB inhibi...

OBJECTIVES Nuclear factor-kB (NF-kB) is a transcription factor that participates in the induction of several genes for cytokines and enzymes that play important functional roles in various cell types. The aim of this study was to determine NF-kB activation status in human colorectal carcinoma and its correlation to the clinicopathological characteristics of patients. MATERIALS AND METHODS We ...