The study by Rose and Behm in this issue (1) is a remarkable first attempt to improve smoking cessation by selecting treatment for individual patients based on an initial test period. Smoking cessation treatments specify a quit date, usually 2 weeks after the initiation of treatment. Rose and Behm used this 2-week period to identify those patients who would likely respond to nicotine replacemen...

Nicotine replacement therapy is often used to maintain smoking cessation. However, concerns exist about the safety of long-term nicotine replacement therapy use in ex-smokers and its concurrent use in smokers. In this study, we determined the effect of nicotine administration on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumors in A/J mice. Female mice were administered a...

Tobacco (nicotine) dependence is the chief preventable cause of respiratory disease. In many ways, nicotine dependence is a chronic medical illness, producing long-lasting structural and functional changes in the central nervous system. Tobacco dependence can be treated, but relapses to smoking are common. The responsibility of physicians to treat tobacco dependence is clear, just as it is to t...

Jed Rose: I think we are far from exploiting the full potential of nicotine itself as a replacement for smoking. At present, fewer than 10 percent of people using nicotine replacement therapy (NRT) achieve longterm smoking cessation. I think the success rate is low because we haven’t yet learned to administer nicotine in a way that reproduces the full effect of nicotine obtained from smoking. A...

Nicotine addiction accounts for 4.9 million deaths each year. Furthermore, although smoking represents a significant health burden in the United States, at present there are only three FDA-approved pharmacotherapies currently on the market: (1) nicotine replacement therapy, (2) bupropion, and (3) varenicline. Despite this obvious gap in the market, the complexity of nicotine addiction in additi...

Background: Tobacco consumption was significantly higher in poor, less educated, scheduled castes and tribe populations. The prevalence of tobacco increased up to the age 50 years then levelled or declined. smoking chewing also varied widely between different states had a strong association with individual’s sociocultural characteristics.ObjectivesTo assess existing level Knowledge Nicotine Rep...