Nigella sativa L. was allegedly to has antibacterial effect. The aim of this research is investigate effect ethanolic extracts 96% from Indonesia toward Staphylococcus aureus, Pseudomonas aeruginosa and Streptococcus epidermidis. Antibacterial activity L epidermidis using the well method. extract 12,5; 25;50 100% (mg/ml)inhibit growth aureus (with inhibition zone 11.06; 29.58; 28.22; 30.84 mm r...

Nigella sativa (N. sativa) (Family Ranunculaceae) have been used for thousands of years as a curative remedy for various disorders. N. sativa seed reveal a broad spectrum of pharmacological activities including immunopotentiation and antihistaminic, antidiabetic, anti-hypertensive, anti-inflammatory, and antimicrobial activities. It is known as a source of thymoquinone, thymohydroquinone, dithy...

An HPLC method was developed for the simultaneous determination of nine compounds of Nigella sativa L. The separation was achieved within 23 min by using C18 column material, a water-acetonitrile mobile phase, both containing 0.1% acetic acid gradient system and a temperature of 35 degrees C. The method was validated for linearity, repeatability, LOD, and LOQ. The LOD and LOQ of nine compounds ...

A deodorizing substance in black cumin (Nigella sativa L.), a spice for curry and vegetable foods in Southwest Asia, was examined. The essential oil prepared from the seeds of this plant exhibited strong deodorizing activity against methyl mercaptan, which is a main factor in oral malodor. After purification with silica gel column chromatography, the active substance in black cumin seed oil was...

The medicinal plants have attracted great attention in the recent years for better therapeutic management of diseases. Nigella sativa is one of the most extensively studied plants and has gained more and more interest for potential medical use in recent years. Historical and traditional uses of this herb have been widely documented in ancient documents; and Nigella sativa have been broadly used...

The objective of the present study was to evaluate the in vitro and in vivo anti-cancer effect of Nigella sativa L. seed extracts. The essential oil (IC50 = 0.6%, v/v) and ethyl acetate (IC50 = 0.75%) extracts were more cytotoxic against the P815 cell line than the butanol extract (IC50 = 2%). Similar results were obtained with the Vero cell line. Although all extracts had a comparable cytotoxi...