The hybrid mouse diversity panel (HMDP), a panel of 100 strains, has been employed in genome wide association studies (GWAS) to study complex traits in mice. Hearing is a complex trait and the CBA/CaJ mouse strain is a widely used model for age-related hearing loss (ARHI) and noise induced hearing loss (NIHL). The CBA/CaJ strain's youthful sensitivity to noise and limited age-related loss led u...

The foundation of the ISO-1999 standard for estimating NIHL in noise-exposed groups is tied to two postulates that form the basis of: (a) an age correction procedure and (b) the use of an energy metric (L eq) to quantify the exposure. This leads to a straightforward relation; NIHL = f(age, L eq). Implicit in such a formulation is that temporal variables associated with a noise exposure are not ...

Noise-induced hearing loss (NIHL) affects a large number of military personnel and civilians. Regenerating inner-ear cochlear hair cells (HCs) is a promising strategy to restore hearing after NIHL. In this review, we first summarize recent transcriptome profile analysis of zebrafish lateral lines and chick utricles where spontaneous HC regeneration occurs after HC damage. We then discuss recent...

Noise-induced hearing loss (NIHL) is caused by cumulative occupational and non-occupational noise exposure. The National Institute for Occupational Safety Health (NIOSH) developed exposure recommendations (85 dBA 8-hour time-weighted average) in 1972. Fifty years later, the NIOSH recommended limit (REL) needs to be revised downwards. In its calculations, assumed that workers have quiet when not...

UNLABELLED Noise Induced Hearing Loss (NIHL) is an insidious and cumulative disease that worsens over the years with work-related noise exposure. AIM To evaluate the noise spectrum influence on NIHL prevalence in workers. MATERIALS AND METHODS This a cross-sectional historical cohort carried out in steel mills, lumber mills and marble shops, with noise levels above 85dB, in which we evaluat...

OBJECTIVE To analyze the prevalence of cases suggestive of noise-induced hearing loss (NIHL) among metalworkers who were potentially exposed to occupational noise (from 83 to 102 dB). METHODS A cross-sectional study was carried out in a metalworking company providing services in Rio de Janeiro, Brazil. Clinical and occupational data on 182 workers who were active between November 2001 and Mar...

BACKGROUND Occupational noise-induced hearing loss (NIHL) occurs in many industries despite interventions such as hearing conservation programmes. AIMS To determine the actual and reported use of hearing protection devices (HPDs) in noise-exposed gold mine workers and their reported knowledge, attitudes and practices relating to NIHL and HPDs. METHODS A cross-sectional descriptive study was...

Noise is defined as an unwanted sound or a combination of sounds that has adverse effects on health. These effects can manifest in the form of physiologic damage or psychological harm through a variety of mechanisms. Chronic noise exposure can cause permanent threshold shifts and loss of hearing in specific frequency ranges. Noise induced hearing loss (NIHL) is thought to be one of the major ca...

The reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) requires adequate normalization in order to ensure accurate results. The use of reference genes is the most common method to normalize RT-qPCR assays; however, many studies have reported that the expression of frequently used reference genes is more variable than expected, depending on experimental conditions. Consequent...

Owing to an increasing number of requests for compensation, a medicolegal decision-making system for tinnitus related to noise-induced hearing loss (NIHL) has been elaborated at the Federal Belgian Institute of Occupational Diseases. Experience with 113 patients, all of them claiming compensation for NIHL and tinnitus, is now available. The patients underwent an exhaustive audiological investig...