We report the case of a five-year-old girl, presenting with difficult-to-treat, symptomatic focal epilepsy, who developed status gelasticus following the introduction of levetiracetam as add-on treatment to oxcarbazepine and diazepam. Gelastic seizures were documented by video-EEG and were responsive to i.v. administration of diazepam. A possible causative role of levetiracetam is suggested. Sp...

Patients in general practice complaining of insomnia of recent origin have been studied in order to ascertain which factors may be of value in the detection of those more susceptible to drug dependence. The type of sleep disturbance was found to be of importance and a personal disturbance scale was found useful as a screening test in two-thirds of the patients. No difference was found in the de...

Astemizole and terfenadine, two potent non-sedative H1 antihistamines, had no effect on itch measured objectively as nocturnal scratching and subjectively on a 10 cm line. Trimeprazine, however, a more sedative but less potent H1 antihistamine, was antipruritic, as was nitrazepam, a sedative benzodiazepine. We concluded (a) that antipruritic drugs act centrally by a property related to sedation...

Abstract Emerging contaminants such as pharmaceutical compounds offer potential hazards to the aquatic environment and human health. In this paper, adsorptive removal of drug Nitrazepam from water was investigated for first time using biochar prepared Sargassum macroalgae. The efficiency 1 g/L macroalgae-derived 98% with a maximum adsorption capacity 143.12 mg/g. Effects solution pH, adsorbent ...

abstract: A simple, accurate and sensitive visible spectrophotometric method for the determination of nimodipine (NMD) and nitrazepam (NTZ) is described. The method is based on the diazotization of reduced drugs with nitrous acid followed by coupling with resorcinol to form colored azo-dye in an alkaline medium. The resulting colored azo-dye exhibits maximum absorption peak at 480 nm for both N...