To elucidate how high dissolved oxygen (DO) favors the startup of nitritation with aerobic granular sludge, two reactors were operated under low (1–2 mg O2·L−1) and DO (3–5 conditions similar effluent ammonium concentrations (>20 N·L−1). The results showed that though an average nitrite accumulation ratio above 95% was finally achieved in both reactors, a five-fold start-up time (eleven weeks) ...