نتایج جستجو برای: nitrosative stress
تعداد نتایج: 438759 فیلتر نتایج به سال:
Stress is a situation in which the cellular redox homoeostasis is altered because of excessive production of different reactive species eg. reactive oxygen species (ROS), reactive nitrogen species (RNS) [1]. The stress which is mediated by ROS like singlet oxygen, superoxide, H2O2 and hydroxyl radicals known as oxidative stress [2]. ROS are produced during cell cycle progression, cell different...
Hydrogen peroxide (H2O2) imposes an oxidative stress to Escherichia coli that is manifested by oxidation of glutathione and related redox-sensitive targets. OxyR is a thiol-containing transcriptional activator whose oxidation controls the expression of genes involved in H2O2 detoxification. Here we report that certain S-nitrosothiols (RSNOs) impose what we term a "nitrosative stress" to E. coli...
Alcohol-related liver disease is the most common cause of worldwide. The purpose this work establishment influence transcription factor κB on development oxidative-nitrosative stress in rats under conditions chronic alcohol intoxication. experiments were performed 24 male Wistar weighing 180-220 g. animals divided into 4 groups 6 animals: control; animals, which administered NF-κB inhibitor, na...
OBJECTIVE Skeletal muscle weakness is a prominent clinical feature in patients with rheumatoid arthritis (RA), but the underlying mechanism(s) is unknown. Here we investigate the mechanisms behind arthritis-induced skeletal muscle weakness with special focus on the role of nitrosative stress on intracellular Ca(2+) handling and specific force production. METHODS Nitric oxide synthase (NOS) ex...
To cite: Yamada T, Fedotovskaya O, Cheng AJ, et al. Ann Rheum Dis Published Online First: [please include Day Month Year] doi:10.1136/ annrheumdis-2013-205007 ABSTRACT Objective Skeletal muscle weakness is a prominent clinical feature in patients with rheumatoid arthritis (RA), but the underlying mechanism(s) is unknown. Here we investigate the mechanisms behind arthritis-induced skeletal muscl...
Nitrosative modifications regulate cellular signal transduction and pathogenesis of inflammatory responses and neurodegenerative diseases. Protein tyrosine nitration is a biomarker of oxidative stress and also influences protein structure and function. Recent advances in mass spectrometry have made it possible to identify modified proteins and specific modified amino acid residues. For analysis...
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