9.1 Saturation Transfer Difference NMR Principle ......... " 149 9.2 STD-NMR for Characterizing Ligand Binding to Membrane Integrated Proteins. . . . . . . . . . . . . . . . . . .. 153 9.3 Epitope Mapping with STD-NMR . . . . . . . . . . . . . . . . . .. 157 9.4 Group Epitope Mapping with STD-NMR .............. l57 9.5 Binding Constants from STD-NMR Experiments ......... 160 9.6 STD-NMR Analysi...

Body's iterative force-field computer program has been used to calculate strain energies in cyclooctanone (I). 348 MHZ 1H NMR spectra of (I) have been investigated over the temperature range of 25° to -160°C. Two conformation processes affect the 1H NMR spectrum of (I). Iterative force-field calculations on the conformations and conformational interconversion paths of ...

α-acyloxycarboxamides are synthesized from three component Passerini reaction between indane-1,2,3-trione, isocyanides, and thiophenecarboxylic acids in quantitative yields. The structures of the final products were confirmed by IR, 1H and 13C NMR spectroscopy, mass spectrometry, and elemental analysis. The B3LYP/HF calculations for computation of 1H an...

LC−NMR has been extensively used for determination and elucidation of chemical structures [1]. In such applications, NMR often suffers poor sensitivity of signal detection. Therefore, stop− flow LC−NMR method, in which flow of LC is stopped when an analyte enters NMR detector, is widely used in order to obtain spectra with sufficient signal to noise ratio to analyze. NMR has been also known tha...

What we call “nuclear magnetic resonance” (NMR) was developed simultaneously but independently by Edward Purcell and Felix Bloch in 1946. The experimental method and theoretical interpretation they developed is now called “continuous-wave NMR” (CWNMR). A different experimental technique, called “pulsed NMR” (PNMR), was introduced in 1950 by Erwin Hahn. Pulsed NMR is used in magnetic resonance i...

The field of zero- to ultralow-field (ZULF) nuclear magnetic resonance (NMR) is currently experiencing a rapid growth, owing the progress in optical magnetometry, and also attractive features ZULF NMR, such as low hardware cost excellent spectral resolution achieved under conditions. In this work, an approach proposed demonstrated for simultaneous acquisition ZULF-NMR spectra individual 13C-con...

The naked mole-rat (NMR, Heterocephalus glaber), which is the longest-lived rodent species, exhibits extraordinary resistance to cancer. Here we report that NMR somatic cells exhibit a unique tumour-suppressor response to reprogramming induction. In this study, we generate NMR-induced pluripotent stem cells (NMR-iPSCs) and find that NMR-iPSCs do not exhibit teratoma-forming tumorigenicity due t...