Purpose: Alzheimer’s disease (AD) is considered as one of the most dangerous diseases in present scenario. It a brain disorder which leads to destruction thinking skills and memory human beings. very much essential for early classification AD magnetic resonance imaging (MRI) preprocessed images (ADMPIs) into several categories such Mild_Demented (MID), Moderate_Demented (MOD), Non_Demented (ND)...

BACKGROUND The number needed to treat (NNT) ratio is an effective method for measuring accuracy in melanoma detection. Dermoscopy reduces the number of false positives and subsequently unnecessary excisions. In vivo reflectance confocal microscopy (RCM) is a noninvasive technique that allows examination of the skin with cellular resolution. OBJECTIVES To assess the impact of RCM analysis on t...

BACKGROUND Droxidopa is an orally active prodrug that significantly improved dizziness/lightheadedness measured using the Orthostatic Hypotension Symptom Assessment (OHSA) Item 1 in patients with neurogenic orthostatic hypotension (nOH) caused by primary autonomic failure (Parkinson disease, multiple system atrophy, and pure autonomic failure), dopamine β-hydroxylase deficiency, or nondiabetic ...

BACKGROUND The causes of bronchopulmonary dysplasia (BPD) are multifactorial. Overdistension of the lung (volutrauma) is considered an important contribution. As an alternative to traditional pressure-limited ventilation (PLV), modern neonatal ventilators offer modes which can target a set tidal volume. OBJECTIVES To determine whether volume-targeted neonatal ventilation, compared with PLV, r...

This article subjects a randomized controlled trial published in the American Journal of Psychiatry to a methodological and statistical critique, including a re-analysis of the effect size statistics presented. The published trial tested the use of combination antidepressants (mirtazapine co-prescribed with either buproprion, venlafaxine, or fluxoetine) at treatment initiation as compared to fl...

BACKGROUND: Hypertension is among the most common chronic condition in middle-aged and older adults. Approximately 50 million Americans are currently diagnosed with this condition, and more than $18.7 billion is spent on hypertension management, including $3.8 billion for medications. There are numerous pharmacological agents that can be chosen to treat hypertension by physicians in clinical pr...

Importance Glioblastoma multiforme (GBM) remains almost invariably fatal despite optimal surgical and medical therapy. The association between the extent of tumor resection (EOR) and outcome remains undefined, notwithstanding many relevant studies. Objective To determine whether greater EOR is associated with improved 1- and 2-year overall survival and 6-month and 1-year progression-free surv...

Background: Arthroscopic surgical repair is a better intervention than non-operative (conservative) treatment for patients with shoulder dislocations. This systematic review determined the numbers-needed-to-treat (NNT) and relative risk reduction (RRR) associated with arthroscopic surgical repair versus non-operative treatment in reducing recurrence rates among patients with first-time traumati...