BACKGROUND Many therapeutic options exist for chronic wounds. Hyperbaric oxygen therapy (HBOT) is one such option. It may be used for diabetic, venous, arterial and pressure ulcers. METHODS Following a systematic search of the literature, pooled analyses of predetermined clinical outcomes of randomized controlled trials involving the use of HBOT for chronic wounds were performed. Relative ris...

Although nicotinamide nucleotide transhydrogenase (NNT)-deficient C57BL/6J (6J) mice are known to be highly susceptible to diet-induced metabolic disease, this notion stems primarily from comparisons of 6J mice to other inbred strains. To date, very few studies have directly compared metabolic disease susceptibility between NNT-deficient 6J mice and NNT-competent C57BL/6 substrains. In this stu...

OBJECTIVE Comparison of the efficacy and tolerability of five newer anti-obesity medications to guide clinical decision making, examining bupropion-naltrexone combination, liraglutide, lorcaserin, orlistat, and phentermine-topiramate combination. METHODS A brief literature review and internet search for high-powered, randomized and placebo-controlled drug trials was conducted. Drug trial info...

BACKGROUND Previous studies have identified various risk factors for neonatal tetanus (NNT) in rural areas of Pakistan. The present matched case control study was conducted to further evaluate these risk factors in an urban setting. AIM The study was carried out to identify risk factors for NNT in Karachi. MATERIALS AND METHODS Patients of NNT (n = 125) diagnosed from January 1998 to Februa...

PURPOSE Venous thromboembolism is a common complication after major orthopedic surgery. When prescribing anticoagulant prophylaxis, clinicians weigh the benefits of thromboprophylaxis against bleeding risk and other adverse events. Previous benefit-risk analyses of the REgulation of Coagulation in ORthopaedic surgery to prevent Deep vein thrombosis and pulmonary embolism (RECORD) randomized cli...

Purpose: Several studies have reported a positive impact for taxanes in adjuvant breast cancer (BC) treatment in terms of reduced recurrence and mortality. However the impact of the magnitude on overall survival (OS) remains partially controversial. Methods: We examined the impact of taxane-containing adjuvant therapy for patients with early BC on OS, based on the number of deaths and on the ca...

OBJECTIVES To examine the efficacy of respiratory physiotherapy for prevention of pulmonary complications after abdominal surgery. METHODS We searched in databases and bibliographies for articles in all languages through November 2005. Randomized trials were included if they investigated prophylactic respiratory physiotherapy and pulmonary outcomes, and if the follow-up was at least 2 days. E...

BACKGROUND Oral pre-exposure prophylaxis (PrEP) can be clinically effective and cost-effective for HIV prevention in high-risk men who have sex with men (MSM). However, individual patients have different risk profiles, real-world populations vary, and no practical tools exist to guide clinical decisions or public health strategies. We introduce a practical model of HIV acquisition, including bo...

Deriving Number-Needed-to-Treat and Number-Needed-to-Harm From the Saint I Trial Results To the Editor: In their recent publication regarding interpretation of the Stroke-Acute Ischemic NXY Treatment (SAINT I) trial,1 Koziol and Feng use the definition, but not the derivation method, for number-needed-to-treat (NNT) and number-needed-to-harm (NNH) that was previously described.2 As a result the...

Evidence Single-agent comparisons: • Ibuprofen versus acetaminophen versus codeine: RCT1 of 336 children with MSK injuries (54% fractures). -At 60 minutes on a 100-mm pain scale, ibuprofen led to —greater mean reduction (-24 mm) versus acetaminophen (-12 mm) or codeine (-11 mm). —more patients achieving adequate analgesia (< 30 mm) versus acetaminophen (number needed to treat [NNT] = 7) or code...