Diabetes is the disease caused due to deficiency of insulin. Antidiabetic drug Gliclazide decreases blood glucose level by inducing insulin. Frequent administration of Gliclazide decreases patient compliance. The present study was aimed to formulate a sustained release formulation of Gliclazide, liposomes. Due to the sustained release property of liposomes it increases patient compliance. Ethan...

Objective(s): Researchers have intended to reformulate drugs so that they may be more safely used in human body. Polymer science and nanotechnology have great roles in this field. The aim of this paper is to introduce an efficient drug delivery vehicle which can perform both targeted and controlled antibiotic release using magnetic nanoparticles grafted pH-responsive polymer.<s...

Objective: The primary goal of this study was to develop a topical gel containing tramadol hydrochloride-loaded Niosomes injection technique as the vesicular carrier for site-specific delivery. Methods: niosomes were created by varying ratios nonionic surfactants (Tween 80, Tween 60, 20, Span and 80) cholesterol while keeping drug concentration constant. Results Discussion: Each formulation exa...

We investigate the temporal scaling properties of mixing in heterogeneous permeability fields with variances ranging from very small (σ lnK = 0.01) to very large (σ lnK = 9). We quantify mixing by the scalar dissipation rate, which we estimate over a large range of temporal scales. For an initial pulse line injection, we find that moderate and strong heterogeneity induce Preprint submitted to E...

Defeat and success of the competitive invasion of a populated area is described with a standard Lotka-Volterra competition model. The resident is adapted to the heterogeneous living conditions, i.e., its motion is modelled as space-dependent, so-called Fokker-Planck diffusion. The invader’s diffusion is taken as neutral Fickian. Furthermore, it is studied how multiplicative environmental noise ...

We consider the Maxwell-Stefan model of diffusion in a multicomponent gaseous mixture. After focusing on the main differences with the Fickian diffusion model, we study the equations governing a three-component gas mixture. Mostly in the case of a tridiagonal diffusion matrix, we provide a qualitative and quantitative mathematical analysis of the model. We develop moreover a standard explicit n...

gum was extracted and characterized by material, proximate pasting properties.Terminalia in combination with sodium alginate at varying concentrations(0-80 %w/v) used preparing the microbeads ionotropic gelation using zincchloride as chelating agent. The were evaluated shape,size, swelling, buoyancy, entrapment efficiency, drug release profiles andkinetic modelling. spherical to ovoid shape siz...

Groundwater age distributions are used to estimate the parameters of Fickian, and non-Fickian, effective models of solute transport. Based on the similarities between the transport and age equations, we develop a deconvolution based approach that describes transport between two monitoring wells. We show that the proposed method gives exact estimates of the travel time distribution between two w...

Diffusion and sorption of Biodegradable blends of sodium alginate (SA) and lignosulphonic acid (LS) has been studied at room temperature by conventional weight gain experiments. The sorption studies of SA/LS blends are carried in pH medium of 7.4. The sorption data are used to evaluate the mass transfer coefficients such as intrinsic diffusion coefficient and permeation coefficient. It was obse...

A model for diffusion in liquids that couples the dynamics of tracer particles to a fluctuating Stokes equation for the fluid is investigated in the limit of large Schmidt number. In this limit, the concentration of tracers is shown to satisfy a closed-form stochastic advection-diffusion equation that is used to investigate the collective diffusion of hydrodynamically-correlated tracers through...