Microcystin-LR (MC-LR) is a potent hepatotoxin for which substantial gap in knowledge persists regarding the underlying molecular mechanisms of liver toxicity and injury. Although long non-coding RNAs (lncRNAs) have been extensively studied model organisms, our concerning role lncRNAs injury limited. Given that show low levels sequence conservation, their becomes even more unclear non-model org...

The purpose of this study was to determine the expression of long non-coding RNA (lncRNA) FTX and analyze its prognostic and biological significance in colorectal cancer (CRC). A quantitative reverse transcription PCR was performed to detect the expression of long non-coding RNA FTX in 35 pairs of colorectal cancer and corresponding noncancerous tissues. The expression of long non-coding RNA FT...

Breast cancer is one of the most frequent causes death among women worldwide. In particular, triple-negative breast (TNBC) represents aggressive subtype because it characterized by absence molecular targets, thus making an orphan type malignancy. The discovery new druggable targets mandatory to improve treatment success. that context, non-coding RNAs represent opportunity for modulation cancer....

Background: As critical regulators, lncRNAs have attracted attention from researchers for diagnostic, prognostic, and therapeutic purposes in human carcinogenesis via interfering with mRNAs such as EZH2. Nevertheless, the potent roles and molecular mechanisms of these RNAs in CRC are not clearly known. Methods: In this study, the tissue expressions of lncRNA MINCR and EZH2 mRNA between colorect...

Advances in both experimental and computational approaches to genome-wide analysis of RNA transcripts have dramatically expanded our understanding of the ubiquitous and diverse roles of regulatory non-coding RNAs. This conference session includes presentations exploring computational approaches for detecting regulatory RNAs in RNA-Seq data, for analyzing in vivo CLIP data on RNA-protein interac...

within the past few years, neat scheme has been overturned by the discovery that rna can act as an enzyme. what does the starting finding of rna enzymes imply? thre first implication is that one can no longer assume a protein lies behind every catalytic activity of the cell. it now appears that several of the operations that tailor an ran molecule into its final form are at least in part cataly...

Only a small proportion of the mouse genome is transcribed into mature messenger RNA transcripts. There is an international collaborative effort to identify all full-length mRNA transcripts from the mouse, and to ensure that each is represented in a physical collection of clones. Here we report the manual annotation of 60,770 full-length mouse complementary DNA sequences. These are clustered in...

Non-coding ribonucleic acid (RNA) has without a doubt captured the interest of biomedical researchers. The ability to screen the entire human genome with high-throughput sequencing technology has greatly enhanced the identification, annotation and prediction of the functionality of non-coding RNAs. In this review, we discuss the current landscape of non-coding RNA research and quantitative anal...

Diseases of the renal filtration unit—the glomerulus—are most common cause chronic kidney disease. Podocytes are pivotal cell type for function this filter and focal-segmental glomerulosclerosis (FSGS) is a classic example podocytopathy leading to proteinuria glomerular scarring. Currently, no targeted treatment FSGS available. This lack therapeutic strategies explained by limited understanding...